No Lewy pathology in monkeys with over 10 years of severe MPTP parkinsonism

Glenda Halliday*, Maria Trinidad Herrero, Karen Murphy, Heather McCann, Francisco Ros-Bernal, Carlos Barcia, Hideo Mori, Francisco J. Blesa, José A. Obeso

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

63 Citations (Scopus)

Abstract

The recent knowledge that 10 years after transplantation surviving human fetal neurons adopt the histopathology of Parkinson's disease suggests that Lewy body formation takes a decade to achieve. To determine whether similar histopathology occurs in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-primate models over a similar timeframe, the brains of two adult monkeys made parkinsonian in their youth with intermittent injections of MPTP were studied. Despite substantial nigral degeneration and increased α-synuclein immunoreactivity within surviving neurons, there was no evidence of Lewy body formation. This suggests that MPTP-induced oxidative stress and inflammation per se are not sufficient for Lewy body formation, or Lewy bodies are human specific.

Original languageEnglish
Pages (from-to)1519-1523
Number of pages5
JournalMovement Disorders
Volume24
Issue number10
DOIs
Publication statusPublished - 30 Jul 2009

Keywords

  • α-synuclein
  • Monkeys
  • MPTP
  • Parkinsonism
  • Substantia nigra

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