No increase in micronuclei frequency in cultured blood lymphocytes from a group of filling station attendants

M. Pitarque, E. Carbonell, N. Lapeña, M. Marsá, M. Torres, A. Creus, N. Xamena, R. Marcos

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40 Citations (Scopus)

Abstract

Service station attendants are workers that are definitely exposed to petroleum derivatives. Taking into account that this exposure has been considered to possess genotoxic risk, here we present data on the biomonitoring of a group of 50 service station workers and 43 controls. Micronuclei (MN) from peripheral blood lymphocytes has been considered as the genetic endpoint to be studied and, in addition, data on the concentration of aromatic hydrocarbons at the workplace, urinary metabolites and differential white blood cell count have also been analysed. The results obtained indicate no significant differences between petrol station attendants and controls, when the effects of petrol exposure were investigated by differential white blood cell count and analysis of MN frequencies in phytohaemagglutinin-stimulated lymphocytes. Regarding the urinary metabolites, a significant increase in the phenol level was found in the exposed workers.
Original languageEnglish
Pages (from-to)161-167
JournalMutation Research - Genetic Toxicology
Volume367
Issue number3
DOIs
Publication statusPublished - 1 Jan 1996

Keywords

  • Biomonitoring
  • Human lymphocyte
  • Micronucleus
  • Petroleum derivative
  • Service station worker
  • White blood cell count

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