No increase in micronuclei frequency in cultured blood lymphocytes from a group of filling station attendants

M. Pitarque; E. Carbonell; N. Lapeña; M. Marsá; M. Torres; A. Creus; N. Xamena; R. Marcos

doi:10.1016/0165-1218(95)00091-7

No increase in micronuclei frequency in cultured blood lymphocytes from a group of filling station attendants

M. Pitarque, E. Carbonell, N. Lapeña, M. Marsá, M. Torres, A. Creus, N. Xamena, R. Marcos

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Abstract

Service station attendants are workers that are definitely exposed to petroleum derivatives. Taking into account that this exposure has been considered to possess genotoxic risk, here we present data on the biomonitoring of a group of 50 service station workers and 43 controls. Micronuclei (MN) from peripheral blood lymphocytes has been considered as the genetic endpoint to be studied and, in addition, data on the concentration of aromatic hydrocarbons at the workplace, urinary metabolites and differential white blood cell count have also been analysed. The results obtained indicate no significant differences between petrol station attendants and controls, when the effects of petrol exposure were investigated by differential white blood cell count and analysis of MN frequencies in phytohaemagglutinin-stimulated lymphocytes. Regarding the urinary metabolites, a significant increase in the phenol level was found in the exposed workers.

Original language	English
Pages (from-to)	161-167
Journal	Mutation Research - Genetic Toxicology
Volume	367
Issue number	3
DOIs	https://doi.org/10.1016/0165-1218(95)00091-7
Publication status	Published - 1 Jan 1996

Keywords

Biomonitoring
Human lymphocyte
Micronucleus
Petroleum derivative
Service station worker
White blood cell count

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10.1016/0165-1218(95)00091-7

Cite this

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title = "No increase in micronuclei frequency in cultured blood lymphocytes from a group of filling station attendants",

abstract = "Service station attendants are workers that are definitely exposed to petroleum derivatives. Taking into account that this exposure has been considered to possess genotoxic risk, here we present data on the biomonitoring of a group of 50 service station workers and 43 controls. Micronuclei (MN) from peripheral blood lymphocytes has been considered as the genetic endpoint to be studied and, in addition, data on the concentration of aromatic hydrocarbons at the workplace, urinary metabolites and differential white blood cell count have also been analysed. The results obtained indicate no significant differences between petrol station attendants and controls, when the effects of petrol exposure were investigated by differential white blood cell count and analysis of MN frequencies in phytohaemagglutinin-stimulated lymphocytes. Regarding the urinary metabolites, a significant increase in the phenol level was found in the exposed workers.",

keywords = "Biomonitoring, Human lymphocyte, Micronucleus, Petroleum derivative, Service station worker, White blood cell count",

author = "M. Pitarque and E. Carbonell and N. Lape{\~n}a and M. Mars{\'a} and M. Torres and A. Creus and N. Xamena and R. Marcos",

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doi = "10.1016/0165-1218(95)00091-7",

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TY - JOUR

T1 - No increase in micronuclei frequency in cultured blood lymphocytes from a group of filling station attendants

AU - Pitarque, M.

AU - Carbonell, E.

AU - Lapeña, N.

AU - Marsá, M.

AU - Torres, M.

AU - Creus, A.

AU - Xamena, N.

AU - Marcos, R.

PY - 1996/1/1

Y1 - 1996/1/1

N2 - Service station attendants are workers that are definitely exposed to petroleum derivatives. Taking into account that this exposure has been considered to possess genotoxic risk, here we present data on the biomonitoring of a group of 50 service station workers and 43 controls. Micronuclei (MN) from peripheral blood lymphocytes has been considered as the genetic endpoint to be studied and, in addition, data on the concentration of aromatic hydrocarbons at the workplace, urinary metabolites and differential white blood cell count have also been analysed. The results obtained indicate no significant differences between petrol station attendants and controls, when the effects of petrol exposure were investigated by differential white blood cell count and analysis of MN frequencies in phytohaemagglutinin-stimulated lymphocytes. Regarding the urinary metabolites, a significant increase in the phenol level was found in the exposed workers.

AB - Service station attendants are workers that are definitely exposed to petroleum derivatives. Taking into account that this exposure has been considered to possess genotoxic risk, here we present data on the biomonitoring of a group of 50 service station workers and 43 controls. Micronuclei (MN) from peripheral blood lymphocytes has been considered as the genetic endpoint to be studied and, in addition, data on the concentration of aromatic hydrocarbons at the workplace, urinary metabolites and differential white blood cell count have also been analysed. The results obtained indicate no significant differences between petrol station attendants and controls, when the effects of petrol exposure were investigated by differential white blood cell count and analysis of MN frequencies in phytohaemagglutinin-stimulated lymphocytes. Regarding the urinary metabolites, a significant increase in the phenol level was found in the exposed workers.

KW - Biomonitoring

KW - Human lymphocyte

KW - Micronucleus

KW - Petroleum derivative

KW - Service station worker

KW - White blood cell count

U2 - 10.1016/0165-1218(95)00091-7

DO - 10.1016/0165-1218(95)00091-7

M3 - Article

SN - 0165-1218

VL - 367

SP - 161

EP - 167

JO - Mutation Research - Genetic Toxicology Testing and Biomonitoring of Environmental or Occupational Exposure

JF - Mutation Research - Genetic Toxicology Testing and Biomonitoring of Environmental or Occupational Exposure

IS - 3

ER -

No increase in micronuclei frequency in cultured blood lymphocytes from a group of filling station attendants

Abstract

Keywords

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