No detection of the NS5B S282T mutation in treatment-naïve genotype 1 HCV/HIV-1 coinfected patients using deep sequencing

Sandra Franco, Maria Casadellà, Marc Noguera-Julian, Bonaventura Clotet, Cristina Tural, Roger Paredes, Miguel Angel Martinez

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13 Citations (Scopus)

Abstract

Background: The S282T mutation is the main variant described associated with resistance to nucleos(t)ide analogues hepatitis C virus (HCV) NS5B polymerase inhibitors. Objective: We aimed here to investigate whether this substitution pre-existed in treatment naive HCV/HIV-1 coinfected patients. Study design: NS5B polymerase deep sequencing was performed at a median coverage per base of 4471 in 16 patient samples. Results: No S282T variant was detected in the 16 analyzed samples. Conclusion: This finding is in agreement with the high genetic barrier of nucleoside analogues NS5B polymerase inhibitors and the clinical efficacy of these compounds. © 2013 Elsevier B.V.
Original languageEnglish
Pages (from-to)726-729
JournalJournal of Clinical Virology
Volume58
Issue number4
DOIs
Publication statusPublished - 1 Dec 2013

Keywords

  • Deep sequencing
  • HCV
  • NS5B
  • Resistance
  • S282T

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