NLRP3 polymorphisms and response to interferon-beta in multiple sclerosis patients

Sunny Malhotra, Melissa Sorosina, Jordi Río, Silvia Peroni, Luciana Midaglia, Luisa M. Villar, José C. Álvarez-Cermeño, Ina Schroeder, Federica Esposito, Ferdinando Clarelli, Uwe K. Zettl, Jeannette Lechner-Scott, Nino Spataro, Arcadi Navarro, Giancarlo Comi, Xavier Montalban, Filippo Martinelli-Boneschi, Manuel Comabella

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6 Citations (Scopus)

Abstract

© The Author(s), 2017. We aimed to investigate whether NLR family, pyrin domain containing 3 (NLRP3) polymorphisms are associated with the response to interferon-beta (IFNβ) in multiple sclerosis (MS) patients. A total of 14 NLRP3 polymorphisms were genotyped in a cohort of 665 relapsing-remitting MS patients recruited across 5 centers and classified into responders and non-responders according to clinical-radiological criteria after 1 year of IFNβ treatment. A meta-analysis failed to demonstrate significant associations between the response to IFNβ and NLRP3 polymorphisms. These findings do not support a role of polymorphisms located in the NLRP3 gene and the response to IFNβ in MS patients.
Original languageEnglish
Pages (from-to)1507-1510
JournalMultiple Sclerosis Journal
Volume24
DOIs
Publication statusPublished - 1 Oct 2018

Keywords

  • inflammasome
  • interferon-beta
  • Multiple sclerosis
  • polymorphisms

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    Malhotra, S., Sorosina, M., Río, J., Peroni, S., Midaglia, L., Villar, L. M., Álvarez-Cermeño, J. C., Schroeder, I., Esposito, F., Clarelli, F., Zettl, U. K., Lechner-Scott, J., Spataro, N., Navarro, A., Comi, G., Montalban, X., Martinelli-Boneschi, F., & Comabella, M. (2018). NLRP3 polymorphisms and response to interferon-beta in multiple sclerosis patients. Multiple Sclerosis Journal, 24, 1507-1510. https://doi.org/10.1177/1352458517739137