NLRP3 polymorphisms and response to interferon-beta in multiple sclerosis patients

Sunny Malhotra, Melissa Sorosina, Jordi Río, Silvia Peroni, Luciana Midaglia, Luisa M. Villar, José C. Álvarez-Cermeño, Ina Schroeder, Federica Esposito, Ferdinando Clarelli, Uwe K. Zettl, Jeannette Lechner-Scott, Nino Spataro, Arcadi Navarro, Giancarlo Comi, Xavier Montalban, Filippo Martinelli-Boneschi, Manuel Comabella

Research output: Contribution to journalArticleResearch

6 Citations (Scopus)


© The Author(s), 2017. We aimed to investigate whether NLR family, pyrin domain containing 3 (NLRP3) polymorphisms are associated with the response to interferon-beta (IFNβ) in multiple sclerosis (MS) patients. A total of 14 NLRP3 polymorphisms were genotyped in a cohort of 665 relapsing-remitting MS patients recruited across 5 centers and classified into responders and non-responders according to clinical-radiological criteria after 1 year of IFNβ treatment. A meta-analysis failed to demonstrate significant associations between the response to IFNβ and NLRP3 polymorphisms. These findings do not support a role of polymorphisms located in the NLRP3 gene and the response to IFNβ in MS patients.
Original languageEnglish
Pages (from-to)1507-1510
JournalMultiple Sclerosis Journal
Publication statusPublished - 1 Oct 2018


  • inflammasome
  • interferon-beta
  • Multiple sclerosis
  • polymorphisms


Dive into the research topics of 'NLRP3 polymorphisms and response to interferon-beta in multiple sclerosis patients'. Together they form a unique fingerprint.

Cite this