Ni(II)-catalyzed Michael additions. Part 2: Dynamic kinetic resolution in the reduction of chiral α-hydrazino-β-ketoacid derivatives

Caroline Marchi, Elisenda Trepat, Marcial Moreno-Mañas, Adelina Vallribera, Elies Molins

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Abstract

Relative syn 1,2-hydrazinoalcohols have been prepared through diastereoselective Ni(II)-catalyzed Michael addition of chiral derivatives of acetoacetic acid and of 3-oxostearic acid to dialkyl azodicarboxylates, followed by stereoselective reduction of the keto function. © 2002 Elsevier Science Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)5699-5708
JournalTetrahedron
Volume58
Issue number28
DOIs
Publication statusPublished - 8 Jul 2002

Keywords

  • Chiral induction
  • Conjugate addition
  • Kinetic resolution
  • Nickel catalysis
  • Syn-1,2-hydrazinoalcohol
  • β-ketoacid derivatives

Fingerprint

Dive into the research topics of 'Ni(II)-catalyzed Michael additions. Part 2: Dynamic kinetic resolution in the reduction of chiral α-hydrazino-β-ketoacid derivatives'. Together they form a unique fingerprint.

Cite this