Nigral degeneration correlates with persistent activation of cerebellar Purkinje cells in MPTP-treated monkeys

Paola Heman, Carlos Barcia, Aurora Gómez, Carmen M. Ros, Francisco Ros-Bernal, José Enrique Yuste, Vicente de Pablos, Emiliano Fernandez-Villalba, María Rebeca Toledo-Cárdenas, María Trinidad Herrero

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

Abstract

In the present work we analyze the cerebellum of chronic parkinsonian monkeys in order to clarify whether chronic mesencephalic depletion is associated with long term activation of the cerebellar neurons in chronic Parkinsonism. In our study, we observed a persistent activation of Purkinje cells in the cerebellum of chronic parkinsonian macaques, characterized by the expression of c-Fos, which correlated with dopaminergic degeneration. These results are compatible with the results observed in fMRI in Parkinson's disease patients, and may contribute to the understanding of additional alterations in the brain circuitry in Parkinsonism.

Original languageEnglish
Pages (from-to)89-94
Number of pages6
JournalHistology and Histopathology
Volume27
Issue number1
Publication statusPublished - Jan 2012

Keywords

  • c-Fos
  • Cerebellum
  • MPTP
  • Parkinson's disease
  • Purkinje cells

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