News about therapeutic use of Cannabis and endocannabinoid system

Marta Duran, Joan Ramon Laporte, Dolors Capellà

Research output: Contribution to journalReview articleResearchpeer-review

22 Citations (Scopus)

Abstract

Growing basic research in recent years led to the discovery of the endocannabinoid system with a central role in neurobiology. New evidence suggests a therapeutic potential of cannabinoids in cancer chemotherapy-induced nausea and vomiting as well as in pain, spasticity and other symptoms in multiple sclerosis and movement disorders. Results of large randomized clinical trials of oral and sublingual Cannabis extracts will be known soon and there will be definitive answers to whether Cannabis has any therapeutic potential. Although the immediate future may lie in plant-based medicines, new targets for cannabinoid therapy focuses on the development of endocannabinoid degradation inhibitors which may offer site selectivity not afforded by cannabinoid receptor agonists.
Original languageEnglish
Pages (from-to)390-398
JournalMedicina Clinica
Volume122
Issue number10
DOIs
Publication statusPublished - 20 Mar 2004

Keywords

  • Cannabinoid system
  • Cannabinoids
  • Cannabis
  • Efficacy
  • Nausea and vomiting
  • Pain
  • Spasticity
  • Unwanted effects

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