New Vistas in Transmetalation with Discrete “AgCF<inf>3</inf>” Species: Implications in Pd-Mediated Trifluoromethylation Reactions

Sara Martínez de Salinas, Ángel L. Mudarra, Jordi Benet-Buchholz, Teodor Parella, Feliu Maseras, Mónica H. Pérez-Temprano

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8 Citations (Scopus)

Abstract

© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim This work describes the employment of discrete “AgCF3” complexes as efficient transmetalating agents to PdII to surmount overlooked challenges related to the transmetalation step in Pd-catalyzed trifluoromethylation processes. We report the participation of a unique silver ate (Cs)[Ag(CF3)2] complex, under stoichiometric and catalytic conditions, in the unprecedented one-pot formation of PhCF3 using PhI as starting material. Moreover, we show that the transmetalation step, which is often ignored in these transformations, can also determine the success or failure of the coupling process.
Original languageEnglish
Pages (from-to)11895-11898
JournalChemistry - A European Journal
Volume24
Issue number46
DOIs
Publication statusPublished - 14 Aug 2018

Keywords

  • organometallic synthesis
  • silver
  • structural elucidation
  • transmetalation
  • trifluoromethylation

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