New triazole antifungal agents derived from mercaptomethylisoxazoles

M. Moreno-Mañas; Y. Arredondo; R. Pleixats; M. Teixidó; M. M. Raga; C. Palacín; J. M. Castelló; J. A. Ortiz

doi:10.1002/jhet.5570290631

New triazole antifungal agents derived from mercaptomethylisoxazoles

M. Moreno-Mañas, Y. Arredondo, R. Pleixats, M. Teixidó, M. M. Raga, C. Palacín, J. M. Castelló, J. A. Ortiz

Department of Chemistry

Research output: Contribution to journal › Article › Research › peer-review

28 Citations (Scopus)

Abstract

Several new triazole antifungal agents derived from mercaptomethylisoxazoles of general structure 2-(2,4-dihalogenophenyl)3-((X-isoxazolyl)methylthio)1-(1,2,4-triazol-1-yl)-2-propanol, as well as some selected sulfoxides and sulfones derived thereof, have been synthesized and tested for antifungal activity. Some of these compounds showed good activity against yeasts and dermatophytes.

Original language	English
Pages (from-to)	1557-1560
Journal	Journal of Heterocyclic Chemistry
Volume	29
Issue number	6
DOIs	https://doi.org/10.1002/jhet.5570290631
Publication status	Published - 1 Oct 1992

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abstract = "Several new triazole antifungal agents derived from mercaptomethylisoxazoles of general structure 2-(2,4-dihalogenophenyl)3-((X-isoxazolyl)methylthio)1-(1,2,4-triazol-1-yl)-2-propanol, as well as some selected sulfoxides and sulfones derived thereof, have been synthesized and tested for antifungal activity. Some of these compounds showed good activity against yeasts and dermatophytes.",

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AU - Moreno-Mañas, M.

AU - Arredondo, Y.

AU - Pleixats, R.

AU - Teixidó, M.

AU - Raga, M. M.

AU - Palacín, C.

AU - Castelló, J. M.

AU - Ortiz, J. A.

PY - 1992/10/1

Y1 - 1992/10/1

N2 - Several new triazole antifungal agents derived from mercaptomethylisoxazoles of general structure 2-(2,4-dihalogenophenyl)3-((X-isoxazolyl)methylthio)1-(1,2,4-triazol-1-yl)-2-propanol, as well as some selected sulfoxides and sulfones derived thereof, have been synthesized and tested for antifungal activity. Some of these compounds showed good activity against yeasts and dermatophytes.

AB - Several new triazole antifungal agents derived from mercaptomethylisoxazoles of general structure 2-(2,4-dihalogenophenyl)3-((X-isoxazolyl)methylthio)1-(1,2,4-triazol-1-yl)-2-propanol, as well as some selected sulfoxides and sulfones derived thereof, have been synthesized and tested for antifungal activity. Some of these compounds showed good activity against yeasts and dermatophytes.

U2 - 10.1002/jhet.5570290631

DO - 10.1002/jhet.5570290631

M3 - Article

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SP - 1557

EP - 1560

JO - Journal of Heterocyclic Chemistry

JF - Journal of Heterocyclic Chemistry

IS - 6

ER -

New triazole antifungal agents derived from mercaptomethylisoxazoles

Abstract

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