New trends in the treatment of amyloidosis

Research output: Contribution to journalReview articleResearchpeer-review

Abstract

Amyloidosis is a clinical disorder caused by extracellular deposition of proteins that are normally soluble as insoluble fibrils that damage different organs. More than 20 proteins can form amyloid deposits. All types of amyloid fibrils have a secondary structure with a β folded shape that is characteristic and makes them to adopt a green birefringence after stained with Congo red and viewed under cross-polarized light. Amyloidosis can be acquired or hereditary, systemic or localized, and are classified by the fibril precursor protein. Advances in the knowledge of the pathogenesis of amyloidosis allows the development of new diagnostic and therapeutical schemes that are currently under investigation. © 2011 Elsevier España, S.L. All rights reserved.
Original languageEnglish
Pages (from-to)667-672
JournalMedicina Clinica
Volume138
Issue number15
DOIs
Publication statusPublished - 26 May 2012

Keywords

  • Amyloidosis
  • New treatments
  • Pathogenesis

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