New ruthenium(II) mixed metallocene derived complexes: Synthesis, characterization by X-ray diffraction and evaluation on DNA interaction by atomic force microscopy

M. Helena Garcia; Andreia Valente; Pedro Florindo; Tânia S. Morais; M. Fátima M. Piedade; M. Teresa Duarte; Virtudes Moreno; Francesc X. Avilés; Julia Loreno

doi:10.1016/j.ica.2010.05.034

New ruthenium(II) mixed metallocene derived complexes: Synthesis, characterization by X-ray diffraction and evaluation on DNA interaction by atomic force microscopy

M. Helena Garcia, Andreia Valente, Pedro Florindo, Tânia S. Morais, M. Fátima M. Piedade, M. Teresa Duarte, Virtudes Moreno, Francesc X. Avilés, Julia Loreno

Research output: Contribution to journal › Article › Research › peer-review

27 Citations (Scopus)

Abstract

A new family of Ru(II) mixed metallocene complexes of the type [Ru(η 5 -C 5 H 5 )(η 6 -arene)] [PF 6 ] has been synthesized and fully characterized by NMR and UV-Vis spectroscopy. X-ray analysis of single crystal was achieved for all the complexes and revealed the presence of two enantiomers expected for planar chirality originated by the η 6 coordination of the arene prochiral ligands. Studies of interaction of the new complexes with pBR322 DNA by atomic force microscopy showed very strong and different types of interaction. Antiproliferative tests were examined on human leukemia cancer cells (HL-60) using the MTT assay, and the IC 50 values revealed low antiproliferative activity compared to cisplatin. © 2010 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	3765-3775
Journal	Inorganica Chimica Acta
Volume	363
Issue number	14
DOIs	https://doi.org/10.1016/j.ica.2010.05.034
Publication status	Published - 25 Nov 2010

Keywords

AFM
Biological activity
Cyclopentadienyl ligands
DNA damage
Sandwich ruthenium complexes
X-ray diffraction

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Garcia, M. H., Valente, A., Florindo, P., Morais, T. S., Piedade, M. F. M., Duarte, M. T., Moreno, V., Avilés, F. X., & Loreno, J. (2010). New ruthenium(II) mixed metallocene derived complexes: Synthesis, characterization by X-ray diffraction and evaluation on DNA interaction by atomic force microscopy. Inorganica Chimica Acta, 363(14), 3765-3775. https://doi.org/10.1016/j.ica.2010.05.034

Garcia, M. Helena ; Valente, Andreia ; Florindo, Pedro ; Morais, Tânia S. ; Piedade, M. Fátima M. ; Duarte, M. Teresa ; Moreno, Virtudes ; Avilés, Francesc X. ; Loreno, Julia. / New ruthenium(II) mixed metallocene derived complexes: Synthesis, characterization by X-ray diffraction and evaluation on DNA interaction by atomic force microscopy. In: Inorganica Chimica Acta. 2010 ; Vol. 363, No. 14. pp. 3765-3775.

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title = "New ruthenium(II) mixed metallocene derived complexes: Synthesis, characterization by X-ray diffraction and evaluation on DNA interaction by atomic force microscopy",

abstract = "A new family of Ru(II) mixed metallocene complexes of the type [Ru(η 5 -C 5 H 5 )(η 6 -arene)] [PF 6 ] has been synthesized and fully characterized by NMR and UV-Vis spectroscopy. X-ray analysis of single crystal was achieved for all the complexes and revealed the presence of two enantiomers expected for planar chirality originated by the η 6 coordination of the arene prochiral ligands. Studies of interaction of the new complexes with pBR322 DNA by atomic force microscopy showed very strong and different types of interaction. Antiproliferative tests were examined on human leukemia cancer cells (HL-60) using the MTT assay, and the IC 50 values revealed low antiproliferative activity compared to cisplatin. {\textcopyright} 2010 Elsevier B.V. All rights reserved.",

keywords = "AFM, Biological activity, Cyclopentadienyl ligands, DNA damage, Sandwich ruthenium complexes, X-ray diffraction",

author = "Garcia, {M. Helena} and Andreia Valente and Pedro Florindo and Morais, {T{\^a}nia S.} and Piedade, {M. F{\'a}tima M.} and Duarte, {M. Teresa} and Virtudes Moreno and Avil{\'e}s, {Francesc X.} and Julia Loreno",

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Garcia, MH, Valente, A, Florindo, P, Morais, TS, Piedade, MFM, Duarte, MT, Moreno, V, Avilés, FX & Loreno, J 2010, 'New ruthenium(II) mixed metallocene derived complexes: Synthesis, characterization by X-ray diffraction and evaluation on DNA interaction by atomic force microscopy', Inorganica Chimica Acta, vol. 363, no. 14, pp. 3765-3775. https://doi.org/10.1016/j.ica.2010.05.034

New ruthenium(II) mixed metallocene derived complexes: Synthesis, characterization by X-ray diffraction and evaluation on DNA interaction by atomic force microscopy. / Garcia, M. Helena; Valente, Andreia; Florindo, Pedro; Morais, Tânia S.; Piedade, M. Fátima M.; Duarte, M. Teresa; Moreno, Virtudes; Avilés, Francesc X.; Loreno, Julia.

In: Inorganica Chimica Acta, Vol. 363, No. 14, 25.11.2010, p. 3765-3775.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - New ruthenium(II) mixed metallocene derived complexes: Synthesis, characterization by X-ray diffraction and evaluation on DNA interaction by atomic force microscopy

AU - Garcia, M. Helena

AU - Valente, Andreia

AU - Florindo, Pedro

AU - Morais, Tânia S.

AU - Piedade, M. Fátima M.

AU - Duarte, M. Teresa

AU - Moreno, Virtudes

AU - Avilés, Francesc X.

AU - Loreno, Julia

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AB - A new family of Ru(II) mixed metallocene complexes of the type [Ru(η 5 -C 5 H 5 )(η 6 -arene)] [PF 6 ] has been synthesized and fully characterized by NMR and UV-Vis spectroscopy. X-ray analysis of single crystal was achieved for all the complexes and revealed the presence of two enantiomers expected for planar chirality originated by the η 6 coordination of the arene prochiral ligands. Studies of interaction of the new complexes with pBR322 DNA by atomic force microscopy showed very strong and different types of interaction. Antiproliferative tests were examined on human leukemia cancer cells (HL-60) using the MTT assay, and the IC 50 values revealed low antiproliferative activity compared to cisplatin. © 2010 Elsevier B.V. All rights reserved.

KW - AFM

KW - Biological activity

KW - Cyclopentadienyl ligands

KW - DNA damage

KW - Sandwich ruthenium complexes

KW - X-ray diffraction

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