New ruthenium(II) mixed metallocene derived complexes: Synthesis, characterization by X-ray diffraction and evaluation on DNA interaction by atomic force microscopy

M. Helena Garcia, Andreia Valente, Pedro Florindo, Tânia S. Morais, M. Fátima M. Piedade, M. Teresa Duarte, Virtudes Moreno, Francesc X. Avilés, Julia Loreno

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27 Citations (Scopus)

Abstract

A new family of Ru(II) mixed metallocene complexes of the type [Ru(η 5 -C 5 H 5 )(η 6 -arene)] [PF 6 ] has been synthesized and fully characterized by NMR and UV-Vis spectroscopy. X-ray analysis of single crystal was achieved for all the complexes and revealed the presence of two enantiomers expected for planar chirality originated by the η 6 coordination of the arene prochiral ligands. Studies of interaction of the new complexes with pBR322 DNA by atomic force microscopy showed very strong and different types of interaction. Antiproliferative tests were examined on human leukemia cancer cells (HL-60) using the MTT assay, and the IC 50 values revealed low antiproliferative activity compared to cisplatin. © 2010 Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)3765-3775
JournalInorganica Chimica Acta
Volume363
Issue number14
DOIs
Publication statusPublished - 25 Nov 2010

Keywords

  • AFM
  • Biological activity
  • Cyclopentadienyl ligands
  • DNA damage
  • Sandwich ruthenium complexes
  • X-ray diffraction

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