New palladium(II) and platinum(II) complexes with 9-aminoacridine: Structures, luminiscence, theoretical calculations, and antitumor activity

José Ruiz, Julia Lorenzo, Consuelo Vicente, Gregorio López, José María López-de-Luzuriaga, Miguel Monge, Francesc X. Avilés, Delia Bautista, Virtudes Moreno, Antonio Laguna

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Abstract

The new complexes [Pd(dmba)(N10-9AA)(PPh3)]ClO4 (1), [Pt(dmba)(N9-9AA)(PPh3)]ClO4 (2), [Pd(dmba)(N10-9AA)Cl] (3), and [Pd(C6F5)(N10-9AA)(PPh3)Cl] (4) (9-AA = 9-aminoacridine; dmba = N,C-chelating 2-(dimethylaminomethyl)phenyl) have been prepared. The crystal structures have been established by X-ray diffraction. In complex 2, an anagostic C-H⋯Pt interaction is observed. All complexes are luminescent in the solid state at room temperature, showing important differences between the palladium and platinum complexes. Complex 2 shows two structured emission bands at high and low energies in the solid state, and the lifetimes are in agreement with excited states of triplet parentage. Density functional theory and time-dependent density functional theory calculations for complex 2 have been done. Values of IC50 were also calculated for the new complexes 1 -4 against the tumor cell line HL-60. All of the new complexes were more active than cisplatin (up to 30-fold in some cases). The DNA adduct formation of the new complexes synthesized was followed by circular dichroism and electrophoretic mobility. Atomic force microscopy images of the modifications caused by the complexes on plasmid DNA pBR322 were also obtained. © 2008 American Chemical Society.
Original languageEnglish
Pages (from-to)6990-7001
JournalInorganic Chemistry
Volume47
DOIs
Publication statusPublished - 4 Aug 2008

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    Ruiz, J., Lorenzo, J., Vicente, C., López, G., López-de-Luzuriaga, J. M., Monge, M., Avilés, F. X., Bautista, D., Moreno, V., & Laguna, A. (2008). New palladium(II) and platinum(II) complexes with 9-aminoacridine: Structures, luminiscence, theoretical calculations, and antitumor activity. Inorganic Chemistry, 47, 6990-7001. https://doi.org/10.1021/ic800589m