New molecular medicine-based scar management strategies

Anna I. Arno, Gerd G. Gauglitz, Juan P. Barret, Marc G. Jeschke

    Research output: Contribution to journalReview articleResearchpeer-review

    29 Citations (Scopus)

    Abstract

    Keloids and hypertrophic scars are prevalent disabling conditions with still suboptimal treatments. Basic science and molecular-based medicine research have contributed to unravel new bench-to-bedside scar therapies and to dissect the complex signalling pathways involved. Peptides such as the transforming growth factor beta (TGF-β) superfamily, with Smads, Ski, SnoN, Fussels, endoglin, DS-Sily, Cav-1p, AZX100, thymosin-β4 and other related molecules may emerge as targets to prevent and treat keloids and hypertrophic scars. The aim of this review is to describe the basic complexity of these new molecular scar management strategies and point out new fibrosis research lines. © 2013 Elsevier Ltd and ISBI.
    Original languageEnglish
    Pages (from-to)539-551
    JournalBurns
    Volume40
    Issue number4
    DOIs
    Publication statusPublished - 1 Jan 2014

    Keywords

    • Endoglin
    • FAP-alpha/DPPIV
    • Fussels
    • Keloid
    • Rapamycin
    • Review
    • Scar
    • Ski
    • SnoN
    • TGF-β

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