Projects per year
Abstract
Vascular endothelial growth factor A (VEGF-A) is classically viewed as a key factor in angiogenesis and tissue remodeling. However, recent evidence suggests a potential role of this growth factor in the control of energy metabolism and adipose tissue function. In this regard, we and others have described the effects of the up and downregulation of VEGF-A in adipose tissue on the control of energy homeostasis. VEGF-A overexpression protects against diet-induced obesity and insulin resistance. The observation that VEGF-A overexpression leads to an increase in brown adipose tissue (BAT) thermogenesis and also promotes a "BAT-like" phenotype in white adipose tissue depots is of particular relevance for the understanding of the mechanisms underlying obesity development. In addition, VEGF-A may not only have pro-inflammatory but also anti-inflammatory properties, with a chemotactic activity specific for M2 anti-inflammatory macrophages. This new scientific evidence highlights the importance that VEGF-A actions on metabolism could have on the design of new treatments for obesity, insulin resistance and obesity-related disorders.
Original language | English |
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Pages (from-to) | 109-112 |
Number of pages | 4 |
Journal | Adipocyte |
Volume | 2 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1 Apr 2013 |
Keywords
- VEGF-A
- adipose tissue
- inflammation
- insulin resistance
- obesity
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- 3 Finished
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Ingenieria Genetica del Musculo Esqueletico para Expresar Insulina y/o Glucoquinasa para el Tratamineto de la Diabetes Mellitus
Bosch Tubert, M. F., Ayuso López, E., Callejas Castiñeiras, D., Elias Puigdomenech, I., Haurigot Mendoça, V., Jimenez Cenzano, V., Lage Fernandez, R., León Madrenas, X., Maggioni , L., Mallol Dominguez, C., Molas Laplana, M., Morro Larrubia, M., Otaegui Goya, P. J., Ribera Sanchez, A., Vila Prats, L., Villacampa Alcubierre, P. & Casellas Comallonga, A.
1/01/12 → 31/12/14
Project: Research Projects and Other Grants
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Estudio del papel de los factores de crecimiento similares a la insulina en la regeneración de la célula B pancreática
Bosch Tubert, M. F., Anguela Martínez, X., Ribera Sanchez, A., Ruzo Matías, A., León Madrenas, X., Agudo Cantero, J., Ayuso López, E., Casellas Comallonga, A., Ferré Masferrer, M. D. T., García Martínez, M., Otaegui Goya, P. J. & Pujol, A.
1/01/09 → 31/12/11
Project: Research Projects and Other Grants
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The European Mouse Disease Clinic: A distributed phenotyping resource for studying human disease (EUMODIC)
1/02/07 → 31/01/11
Project: International research project