New imidazole anti-fungal agents derived from benzo[b]thiophene. Part II

Marcial Moreno-Mañas; Ma Rosa Cuberes; Celia Palacín; Manuel Raga; Josep M. Castello; JoséA Ortiz

doi:10.1016/0223-5234(88)90146-8

New imidazole anti-fungal agents derived from benzo[b]thiophene. Part II

Marcial Moreno-Mañas, Ma Rosa Cuberes, Celia Palacín, Manuel Raga, Josep M. Castello, JoséA Ortiz

Department of Chemistry

Research output: Contribution to journal › Article › Research › peer-review

6 Citations (Scopus)

Abstract

1-[(Aryl)(benzo[b]thienyl)methyl]-1H-imidazoles 22, 1-[(benzo[b]thien-3-yl)(thienyl)methyl]-1H-imidazoles 25 and 1-[(diaryl)(benzo[b]thien-3-yl)methyl]-1H-imidazoles 28 have been synthesized and tested for anti-fungal activity. All compounds showed good activity against a broad spectrum of fungi (yeasts, dermatophytes). © 1988.

Original language	English
Pages (from-to)	477-482
Journal	European Journal of Medicinal Chemistry
Volume	23
Issue number	5
DOIs	https://doi.org/10.1016/0223-5234(88)90146-8
Publication status	Published - 1 Jan 1988

Keywords

anti-fungal activity
benzo[b]thienyl anti-fungal agents
imidazole anti-fungal agents
structure-activity relationships

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Cite this

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title = "New imidazole anti-fungal agents derived from benzo[b]thiophene. Part II",

abstract = "1-[(Aryl)(benzo[b]thienyl)methyl]-1H-imidazoles 22, 1-[(benzo[b]thien-3-yl)(thienyl)methyl]-1H-imidazoles 25 and 1-[(diaryl)(benzo[b]thien-3-yl)methyl]-1H-imidazoles 28 have been synthesized and tested for anti-fungal activity. All compounds showed good activity against a broad spectrum of fungi (yeasts, dermatophytes). {\textcopyright} 1988.",

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author = "Marcial Moreno-Ma{\~n}as and Cuberes, {Ma Rosa} and Celia Palac{\'i}n and Manuel Raga and Castello, {Josep M.} and Jos{\'e}A Ortiz",

year = "1988",

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doi = "10.1016/0223-5234(88)90146-8",

language = "English",

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T1 - New imidazole anti-fungal agents derived from benzo[b]thiophene. Part II

AU - Moreno-Mañas, Marcial

AU - Cuberes, Ma Rosa

AU - Palacín, Celia

AU - Raga, Manuel

AU - Castello, Josep M.

AU - Ortiz, JoséA

PY - 1988/1/1

Y1 - 1988/1/1

N2 - 1-[(Aryl)(benzo[b]thienyl)methyl]-1H-imidazoles 22, 1-[(benzo[b]thien-3-yl)(thienyl)methyl]-1H-imidazoles 25 and 1-[(diaryl)(benzo[b]thien-3-yl)methyl]-1H-imidazoles 28 have been synthesized and tested for anti-fungal activity. All compounds showed good activity against a broad spectrum of fungi (yeasts, dermatophytes). © 1988.

AB - 1-[(Aryl)(benzo[b]thienyl)methyl]-1H-imidazoles 22, 1-[(benzo[b]thien-3-yl)(thienyl)methyl]-1H-imidazoles 25 and 1-[(diaryl)(benzo[b]thien-3-yl)methyl]-1H-imidazoles 28 have been synthesized and tested for anti-fungal activity. All compounds showed good activity against a broad spectrum of fungi (yeasts, dermatophytes). © 1988.

KW - anti-fungal activity

KW - benzo[b]thienyl anti-fungal agents

KW - imidazole anti-fungal agents

KW - structure-activity relationships

U2 - 10.1016/0223-5234(88)90146-8

DO - 10.1016/0223-5234(88)90146-8

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IS - 5

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