New chromosomal alterations in a series of 23 splenic marginal zone lymphoma patients revealed by Spectral Karyotyping (SKY)

Cristina Baró, Marta Salido, Blanca Espinet, Laura Astier, Alicia Domingo, Isabel Granada, Fuensanta Millà, Ana Carrió, Dolors Costa, Elisa Luño, Jesús Ma Hernández, Elias Campo, Lourdes Florensa, Ana Ferrer, Antonio Salar, Beatriz Bellosillo, Carles Besses, Sergi Serrano, Francesc Solé

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16 Citations (Scopus)

Abstract

Splenic marginal zone lymphoma (SMZL) is a B-cell lymphoproliferative disorder with characteristic clinical, immunophenotypic, cytological and histological features. Some karyotypic abnormalities have been related to this disorder and most of them are usually complex and difficult to define. The aim of present study was to characterize new chromosomal aberrations involved in this disease. We performed conventional banding cytogenetics and Spectral Karyotyping (SKY) technique in 23 patients diagnosed with SMZL having a complex karyotype among a series of 160 SMZL cases. Del(7)(q22-q32) and trisomy 3/3q were the most common chromosomal aberrations. In addition, new translocations involving chromosomes 3, 6, 8, 9, 12 and 14q32 region were detected. © 2007 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)727-736
JournalLeukemia Research
Volume32
Issue number5
DOIs
Publication statusPublished - 1 Jan 2008

Keywords

  • Cytogenetics
  • FISH
  • SKY
  • Splenic marginal zone lymphoma

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