New chromosomal abnormality. t(1;19;?) in a case of B-chronic lymphocytic leukemia

Sergi Montero, M. Rosa Caballín, M. Dolors Coll, Carles Besses, Soledad Woessner, Josep Egozcue, Francesc Solé

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Cytogenetic analysis was performed on peripheral blood cells stimulated with interleukin 6 (IL-6), lipopolysaccharide from Escherichia coli (LPS), phytohemagglutinin (PHA), pokeweed mitogen (PWM) and tetradecanoyl-phorbol-acetate (TPA), in a patient with B-chronic lymphocytic leukemia, showing a t(1;19;?) translocation as the sole abnormality. To our knowledge, this translocation has not been described before in any human neoplasia. In this case, the poor response to therapy (survival time 4 months) suggested that t(1;19;?) could be related to an aggressive course of the disease. © 1992.
Original languageEnglish
Pages (from-to)131-134
JournalCancer Genetics and Cytogenetics
Volume60
Issue number2
DOIs
Publication statusPublished - 1 Jan 1992

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