New 2-[(5-methoxy-1-methylindolyl)]-alkylamine derivatives: The effect of branching and elongation of the side chain on MAO inhibition

J. A. Morón; V. Perez; J. L. Marco; E. Fernandez-Alvarez; M. Unzeta

doi:10.3109/14756369809021473

New 2-[(5-methoxy-1-methylindolyl)]-alkylamine derivatives: The effect of branching and elongation of the side chain on MAO inhibition

J. A. Morón, V. Perez, J. L. Marco, E. Fernandez-Alvarez, M. Unzeta

Department of Biochemistry and Molecular Biology

Research output: Contribution to journal › Article › Research › peer-review

3 Citations (Scopus)

Abstract

A novel series of previously synthesised 2-[(5-methoxy-1-methylindolyl)]alkylamine derivatives were irreversible and time-dependent mechanism-based inhibitors of MAO. The effect of branching and elongation of the side chain was evaluated on the inhibitory potency towards MAO-A and MAO-B activities. The K(I) of the reversible step and the k(inact) of the irreversible one were determined in each case. The results obtained lead to the conclusion that neither the elongation nor the branching of the side chain improve the potency of the compounds as MAO inhibitors.

Original language	English
Pages (from-to)	237-251
Journal	Journal of Enzyme Inhibition
Volume	13
Issue number	4
DOIs	https://doi.org/10.3109/14756369809021473
Publication status	Published - 1 Jan 1998

Keywords

Indolalkylamine derivatives
Inhibition
Kinetics
Monoamine oxidase

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title = "New 2-[(5-methoxy-1-methylindolyl)]-alkylamine derivatives: The effect of branching and elongation of the side chain on MAO inhibition",

abstract = "A novel series of previously synthesised 2-[(5-methoxy-1-methylindolyl)]alkylamine derivatives were irreversible and time-dependent mechanism-based inhibitors of MAO. The effect of branching and elongation of the side chain was evaluated on the inhibitory potency towards MAO-A and MAO-B activities. The K(I) of the reversible step and the k(inact) of the irreversible one were determined in each case. The results obtained lead to the conclusion that neither the elongation nor the branching of the side chain improve the potency of the compounds as MAO inhibitors.",

keywords = "Indolalkylamine derivatives, Inhibition, Kinetics, Monoamine oxidase",

author = "Mor{\'o}n, {J. A.} and V. Perez and Marco, {J. L.} and E. Fernandez-Alvarez and M. Unzeta",

year = "1998",

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T1 - New 2-[(5-methoxy-1-methylindolyl)]-alkylamine derivatives: The effect of branching and elongation of the side chain on MAO inhibition

AU - Morón, J. A.

AU - Perez, V.

AU - Marco, J. L.

AU - Fernandez-Alvarez, E.

AU - Unzeta, M.

PY - 1998/1/1

Y1 - 1998/1/1

N2 - A novel series of previously synthesised 2-[(5-methoxy-1-methylindolyl)]alkylamine derivatives were irreversible and time-dependent mechanism-based inhibitors of MAO. The effect of branching and elongation of the side chain was evaluated on the inhibitory potency towards MAO-A and MAO-B activities. The K(I) of the reversible step and the k(inact) of the irreversible one were determined in each case. The results obtained lead to the conclusion that neither the elongation nor the branching of the side chain improve the potency of the compounds as MAO inhibitors.

AB - A novel series of previously synthesised 2-[(5-methoxy-1-methylindolyl)]alkylamine derivatives were irreversible and time-dependent mechanism-based inhibitors of MAO. The effect of branching and elongation of the side chain was evaluated on the inhibitory potency towards MAO-A and MAO-B activities. The K(I) of the reversible step and the k(inact) of the irreversible one were determined in each case. The results obtained lead to the conclusion that neither the elongation nor the branching of the side chain improve the potency of the compounds as MAO inhibitors.

KW - Indolalkylamine derivatives

KW - Inhibition

KW - Kinetics

KW - Monoamine oxidase

U2 - 10.3109/14756369809021473

DO - 10.3109/14756369809021473

M3 - Article

VL - 13

SP - 237

EP - 251

IS - 4

ER -

New 2-[(5-methoxy-1-methylindolyl)]-alkylamine derivatives: The effect of branching and elongation of the side chain on MAO inhibition

Abstract

Keywords

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