Neuroregenerative and neuroprotective actions of neuroimmunophilin compounds in traumatic and inflammatory neuropathies

Bruce G. Gold, Esther Udina, Dennis Bourdette, Xavier Navarro

Research output: Contribution to journalReview articleResearchpeer-review

36 Citations (Scopus)

Abstract

FK506 (tacrolimus, Prograf®) is an immunosuppressant drug that also has profound neuroregenerative and neuroprotective actions independent of its immunosuppressant activity. The separation of these properties has led to the development of non-immunosuppressant derivatives that retain the neurotrophic activity. This review focuses on the peripheral nerve actions of these compounds following mechanical injury (nerve crush or transection with graft repair) and in models of inflammatory neuropathies. Whereas FK506 may be indicative for the treatment of inflammatory neuropathies where its immunosuppressive action would be advantageous, non-immunosuppressant derivatives represent a new class of potential therapeutic agents for the treatment of human neurological conditions in general. Moreover, these studies have led to the discovery of a novel mechanism whereby these compounds activate intrinsic neuroregenerative and neuroprotective pathways in the neuron.
Original languageEnglish
Pages (from-to)371-380
JournalNeurological Research
Volume26
Issue number4
DOIs
Publication statusPublished - 1 Jun 2004

Keywords

  • FK506
  • FKBP
  • Immunosuppressant
  • Inflammatory
  • Nerve regeneration
  • Neuroprotection
  • Sciatic nerve

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