Neuropsychiatric symptoms associated with efavirenz: Prevalence, correlates and management. A neurobehavioral review

José A. Muñoz-Moreno, Carmina R. Fumaz, Maria J. Ferrer, Marian González-Garcia, José Moltó, Eugènia Negredo, Bonaventura Clotet

Research output: Contribution to journalReview articleResearchpeer-review

62 Citations (Scopus)

Abstract

The non-nucleoside analog reverse transcriptase inhibitor efavirenz is one of the most common components of HAART. Neuropsychiatric symptoms are frequently reported in patients taking efavirenzbased regimens. These symptoms are usually transient, although they can sometimes persist for up to two years after initiation of treatment. This review describes in detail the most common neuropsychiatric symptoms related to efavirenz, outlines relevant and recent findings on this agent, and suggests possible interventions based on neurobehavioral results. Different recommendations on the assessment of efavirenz-related adverse events are also provided.
Original languageEnglish
Pages (from-to)103-109
JournalAIDS Reviews
Volume11
Issue number2
Publication statusPublished - 15 Sep 2009

Keywords

  • Antiretroviral therapy
  • Efavirenz
  • HIV infection

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