PF9601N is an acetylenic tryptamine derivative devoid of amphetamine-like properties, that behaves as suicide MAO-B inhibitor more potent than 1-deprenyl. It is highly selective towards MAO-B and it neuroprotects from the neurotoxicity induced in C57B1/6 adult mice by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). PF9601N also shows in vitro antioxidant properties by inhibiting the dopamine autoxidation. A potential therapeutic use in Parkinson's disease treatment is proposed for this compound.
|Publication status||Published - 1 Dec 2000|
- MAO-B inhibitor