Neuropathy and mortality in diabetes: Influence of pancreas transplantation

Xavier Navarro, William R. Kennedy, Dorothee Aeppli, David E.R. Sutherland

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    67 Citations (Scopus)

    Abstract

    We collected information on patient status and cause of death for 545 insulindependent diabetic subjects who had cardiorespiratory reflex and nerve conduction tests performed to determine if presence and severity of autonomic and somatic neuropathy is associated with mortality and if a functioning pancreas transplantation (PTx) influences mortality. Follow-up was 12-138 months. Abnormal cardiorespiratory reflexes were present in 417 patients and there was abnormal nerve conduction in 392 patients. Mortality rates for patients with abnormal tests were higher (P < 0.0001) than for patients with normal tests. A total neuropathy score that included cardiorespiratory and nerve conduction test scores predicted survival better than separate scores. Patients with moderate neuropathy, but not those with severe neuropathy, who retained a functioning PTx, had longer survival times than patients whose PTx failed in the first 3 months. Considering only patients transplanted after 1985, those with moderate neuropathy who retained a functioning PTx had even longer survival times than nontransplanted patients.
    Original languageEnglish
    Pages (from-to)1009-1016
    JournalMuscle and Nerve
    Volume19
    Issue number8
    DOIs
    Publication statusPublished - 1 Aug 1996

    Keywords

    • autonomic neuropathy
    • cardiorespiratory reflex
    • diabetes
    • nerve conduction
    • survival

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