Neuropathologic findings in an aged albino Gorilla

Marti Pumarola Batlle, Hugo Manuel Fernández Bellon, Anna Maria Serafin Canals, M. Márquez, S. Serrat, A. Ferrer-Admetlla, J. Bertranpetit, I. Ferrer

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Abstract

Pallido-nigral spheroids associated with iron deposition have been observed in some aged clinically normal nonhuman primates. In humans, similar findings are observed in neurodegeneration with brain iron accumulation diseases, which, in some cases, show associated mutations in pantothenate kinase 2 gene (PANK2). Here we present an aged gorilla, 40 years old, suffering during the last 2 years of life from progressive tetraparesis, nystagmus, and dyskinesia of the arms, hands, and neck, with accompanying abnormal behavior. The postmortem neuropathologic examination revealed, in addition to aging-associated changes in the brain, numerous corpora amylacea in some brain areas, especially the substantia nigra, and large numbers of axonal spheroids associated with iron accumulation in the internal globus pallidus. Sequencing of the gorilla PANK2 gene failed to detect any mutation. The clinical, neuropathologic, and genetic findings in this gorilla point to an age-related pallido-nigral degeneration that presented PKAN-like neurologic deficits.
Original languageEnglish
Pages (from-to)531-537
JournalVeterinary Pathology
Volume45
DOIs
Publication statusPublished - 1 Jul 2008

Keywords

  • Axonal dystrophy
  • Gorilla
  • Iron
  • Neurodegeneration with brain iron accumulation
  • Nonhuman primate
  • Pallido-nigral degeneration
  • Pantothenate kinase-associated neurodegeneration

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