Neuronal intranuclear inclusion disease in a horse

M. Pumarola*, E. Vidal, J. M. Trens, A. Serafín, I. Ferrer

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)


Neuronal intranuclear inclusion disease (NIID) is reported in a 16-year-old Pure Spanish breed female horse suffering from progressive ataxia and motor deficiencies. The neuropathological study revealed NIIs throughout the central nervous system, although mainly in the brain stem and spinal cord. This distribution did not correlate with neuron loss, which was marked in the hippocampus and moderate in the neocortex, particularly in the occipital cortex. As in humans, NIIs in the horse were hyaline autofluorescent inclusions composed of non-membrane-bound aggregates of filaments and fine granules. NIIs were stained with anti-ubiquitin and anti-clusterin antibodies. In addition, NIIs were stained with antibodies raised against subunits of the 19S and PA28, but not of the 20S, components of the proteasome. These observations indicate similarities between NIID in humans and horses, and suggest that clusterin and abnormal ubiquitin-proteasomal expression participate in NII formation. © Springer-Verlag 2005.
Original languageEnglish
Pages (from-to)191-195
Number of pages5
JournalActa Neuropathologica
Issue number2
Publication statusPublished - 1 Aug 2005


  • Clusterin
  • Horse
  • Neuronal intranuclear inclusion
  • Proteasome


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