Neuroinflammation in Movement Disorders

E. Saavedra-López, P. V. Casanova, G. P. Cribaro, C. Barcia

Research output: Chapter in BookChapterResearchpeer-review

Abstract

© 2017 Elsevier B.V. Neuroinflammation is present in almost every injury of the central nervous system. This response is intended to resolve tissue damage and restore homeostasis. However, in pathological conditions, inflammation may cause direct damage and contribute to neuronal degeneration. Many, if not all, movement disorders show neuroinflammatory changes in the areas of tissue degeneration. Debate still persists on whether these inflammatory changes are a mere consequence or a cause of the local damage. Increasing data suggest the latter, since a broad range of pathological alterations, including genetic, are able to modify the inflammatory scenario and induce or at least contribute to the appearance of movement disorders. In the present chapter, we review inflammatory-mediated alterations in the most prevalent movement disorders, emphasizing the paradigm of Parkinson's disease, and suggest that anti-inflammatory drugs may be a positive therapeutic option for movement disorders.
Original languageEnglish
Title of host publicationHandbook of Behavioral Neuroscience
Pages771-782
Number of pages11
Volume24
DOIs
Publication statusPublished - 1 Jan 2016

Keywords

  • Neuroinflammation
  • T-cell infiltration
  • aging
  • astroglia
  • glial cells
  • macrophages
  • microglia
  • monocytes
  • neurodegeneration

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