NeuroHeal Reduces Muscle Atrophy and Modulates Associated Autophagy

Sara Marmolejo-Martínez-Artesero, David Romeo-Guitart, Laura Mañas-García, Esther Barreiro, Caty Casas

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Abstract

Muscle wasting is an unmet medical need which leads to a reduction of myofiber diameter and a negative impact on the functional performance of daily activities. We previously found that a new neuroprotective drug called NeuroHeal reduced muscle atrophy produced by transient denervation. Aiming to decipher whether NeuroHeal has a direct role in muscle biology, we used herein different models of muscle atrophy: one caused by chronic denervation, another caused by hindlimb immobilization, and lastly, an in vitro model of myotube atrophy with Tumor Necrosis Factor-α (TNFα). In all these models, we observed that NeuroHeal reduced muscle atrophy and that SIRT1 activation seems to be required for that. The treatment downregulated some critical markers of protein degradation: Muscle Ring Finger 1 (MuRF1), K48 poly-Ub chains, and p62/SQSTM1. Moreover, it seems to restore the autophagy flux associated with denervation. Hence, we envisage a prospective use of NeuroHeal at clinics for different myopathies.

Original languageEnglish
Article number9071575
Number of pages16
JournalCells
Volume9
Issue number7
DOIs
Publication statusPublished - 28 Jun 2020

Keywords

  • autophagy
  • NeuroHeal
  • proteasome
  • sirtuin 1
  • skeletal muscle atrophy

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