Neural correlates of obsessive-compulsive related dysfunctional beliefs

Pino Alonso, Arantxa Orbegozo, Jesús Pujol, Clara López-Solà, Miquel Àngel Fullana, Cinto Segalàs, Eva Real, Marta Subirà, Ignacio Martínez-Zalacaín, José M. Menchón, Ben J. Harrison, Narcís Cardoner, Carles Soriano-Mas

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)


There have been few attempts to integrate neurobiological and cognitive models of obsessive-compulsive disorder (OCD), although this might constitute a key approach to clarify the complex etiology of the disorder. Our study aimed to explore the neural correlates underlying dysfunctional beliefs hypothesized by cognitive models to be involved in the development and maintenance of OCD. We obtained a high-resolution magnetic resonance image from fifty OCD patients and 30 healthy controls, and correlated them, voxel-wise, with the severity of OC-related dysfunctional beliefs assessed by the Obsessive Beliefs Questionnaire-44. In healthy controls, significant negative correlations were observed between anterior temporal lobe (ATL) volume and scores on perfectionism/intolerance of uncertainty and overimportance/need to control thoughts. No significant correlations between OBQ-44 domains and regional gray matter volumes were observed in OCD patients. A post-hoc region-of-interest analysis detected that the ATLs was bilaterally smaller in OCD patients. On splitting subjects into high- and low-belief subgroups, we observed that such brain structural differences between OCD patients and healthy controls were explained by significantly larger ATL volumes among healthy subjects from the low-belief subgroup. Our results suggest a significant correlation between OC-related dysfunctional beliefs and morphometric variability in the anterior temporal lobe, a brain structure related to socio-emotional processing. Future studies should address the interaction of these correlations with environmental factors to fully characterize the bases of OC-related dysfunctional beliefs and to advance in the integration of biological and cognitive models of OCD. © 2013 Elsevier Inc.
Original languageEnglish
Pages (from-to)25-32
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Publication statusPublished - 2 Dec 2013


  • Anterior temporal lobe
  • Cognition
  • Magnetic resonance image
  • Obsessive-compulsive disorder
  • Obsessive-compulsive-related dysfunctional beliefs


Dive into the research topics of 'Neural correlates of obsessive-compulsive related dysfunctional beliefs'. Together they form a unique fingerprint.

Cite this