Abstract
The role of the serotonergic transmission on the negative feedback of corticosterone on the pituitary-adrenal (PA) axis was studied in adult male rats. Animals were given p-chlorophenylalaine (PCPA) and 24 h later were administered corticosterone, 2 h before being subjected to 20 min of noise stress. The main results were as follows: First, PCPA administration increased resting levels of both corticotropin (ACTH) and corticosterone but did not alter PA response to noise stress; second. ACTH response to stress was eliminated in rats given PCPA; third, corticosterone reduced ACTH levels in nonstressed rats only and this effect was maintained after PCPA administration. Taken together, the present results suggest a mediator role for serotonin in the noise-stress-induced PA hormone release but no role in the negative feedback of corticosterone on the PA axis. © 1992.
Original language | English |
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Pages (from-to) | 915-918 |
Journal | Brain Research Bulletin |
Volume | 28 |
Issue number | 6 |
DOIs | |
Publication status | Published - 1 Jan 1992 |
Keywords
- p-Chlorophenylalanine Serotonin ACTH Corticosterone Negative feedback Noise Stress