Needle tract seeding and malignant transformation of hepatocellular adenoma into well-differentiated hepatocellular carcinoma in a dog

Oriol Jornet-Rius, Beatriz Agulla, Maria Cristina López, Clàudia Viñeta, A. García-Ferrer, Bárbara Serrano, Alberto Marco Valle, Anna Palomares Solà, Rosa Novellas Torroja, Yvonne Espada, Xavier Roura, Laia Solano Gallego

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

An 11-year-old neutered female Golden Retriever was referred for investigation of marked increases in liver enzyme activities. Abdominal ultrasound revealed a large pedunculated liver mass. Diagnosis of hepatocellular adenoma (HCA) was made when the mass was excised after a first unsuccessful attempt through ultrasound-guided core-needle biopsy. One and a half years after presentation, a nodule embedded between muscles of the abdominal wall appeared. The mass was first diagnosed as a well-differentiated hepatocellular carcinoma (HCC) through cytologic examination, which was later confirmed with histopathology. Ki 67 immunostaining of the abdominal wall nodule showed an increased immunoreactivity compared with the liver mass. Therefore, the present case documents the first needle-tract seeding of a hepatocellular epithelial tumor with possible malignant transformation of HCA into a well-differentiated HCC in a dog.
Original languageEnglish
Pages (from-to)507-513
Number of pages7
JournalVeterinary Clinical Pathology
Volume52
Issue number3
DOIs
Publication statusPublished - Sept 2023

Keywords

  • Canine
  • Implantation
  • Liver
  • Metastasis
  • Neoplasia
  • implantation
  • liver
  • metastasis
  • canine
  • neoplasia
  • Neoplasm Seeding
  • Dog Diseases/diagnostic imaging
  • Animals
  • Adenoma, Liver Cell/diagnosis
  • Dogs
  • Carcinoma, Hepatocellular/diagnosis
  • Liver Neoplasms/diagnosis
  • Female

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