TY - JOUR
T1 - NEDD 9 an independent good prognostic factor in intermediaterisk acute myeloid leukemia patients
AU - Pallarès, Victor
AU - Hoyos, Montserrat
AU - Chillón, M. Carmen
AU - Barragán, Eva
AU - Conde, M. Isabel Prieto
AU - Llop, Marta
AU - Céspedes, María Virtudes
AU - Nomdedeu, Josep F.
AU - Brunet, Salut
AU - Sanz, Miguel Ángel
AU - González-Díaz, Marcos
AU - Sierra, Jorge
AU - Casanova, Isolda
AU - Mangues, Ramon
PY - 2017/1/1
Y1 - 2017/1/1
N2 - © Pallarès et al. Intermediate-risk acute myeloid leukemia (IR-AML) is the largest subgroup of AML patients and is highly heterogeneous. Whereas adverse and favourable risk patients have well-established treatment protocols, IR-AML patients have not. It is, therefore, crucial to find novel factors that stratify this subgroup to implement risk-adapted strategies. The CAS (Crk-associated substrate) adaptor protein family regulates cell proliferation, survival, migration and adhesion. Despite its association with metastatic dissemination and prognosis of different solid tumors, the role of these proteins in hematological malignancies has been scarcely evaluated. Nevertheless, previous work has established an important role for the CAS family members NEDD9 or BCAR1 in the migratory and dissemination capacities of myeloid cells. On this basis, we hypothesized that NEDD9 or BCAR1 expression levels could associate with survival in IR-AML patients and become new prognostic markers. To that purpose, we assessed BCAR1 and NEDD9 gene expression in a cohort of 73 adult AML patients validating the results in an independent cohort (n = 206). We have identified NEDD9, but not BCAR1, as a new a marker for longer overall and disease-free survival, and for lower cumulative incidence of relapse. In summary, NEDD9 gene expression is an independent prognostic factor for favourable prognosis in IR-AML patients.
AB - © Pallarès et al. Intermediate-risk acute myeloid leukemia (IR-AML) is the largest subgroup of AML patients and is highly heterogeneous. Whereas adverse and favourable risk patients have well-established treatment protocols, IR-AML patients have not. It is, therefore, crucial to find novel factors that stratify this subgroup to implement risk-adapted strategies. The CAS (Crk-associated substrate) adaptor protein family regulates cell proliferation, survival, migration and adhesion. Despite its association with metastatic dissemination and prognosis of different solid tumors, the role of these proteins in hematological malignancies has been scarcely evaluated. Nevertheless, previous work has established an important role for the CAS family members NEDD9 or BCAR1 in the migratory and dissemination capacities of myeloid cells. On this basis, we hypothesized that NEDD9 or BCAR1 expression levels could associate with survival in IR-AML patients and become new prognostic markers. To that purpose, we assessed BCAR1 and NEDD9 gene expression in a cohort of 73 adult AML patients validating the results in an independent cohort (n = 206). We have identified NEDD9, but not BCAR1, as a new a marker for longer overall and disease-free survival, and for lower cumulative incidence of relapse. In summary, NEDD9 gene expression is an independent prognostic factor for favourable prognosis in IR-AML patients.
KW - Acute myeloid leukemia
KW - Bcar1
KW - Intermediate-risk
KW - Nedd9
KW - Prognostic factor
U2 - https://doi.org/10.18632/oncotarget.18537
DO - https://doi.org/10.18632/oncotarget.18537
M3 - Article
VL - 8
SP - 76003
EP - 76014
JO - Oncotarget
JF - Oncotarget
SN - 1949-2553
IS - 44
ER -