Nature of neuronal uptake and noradrenaline-adrenaline effects in the isolated rat vas deferens

Jesús A. Garcia-Sevilla; Albert Badia; Josep Laporte

doi:10.1016/0014-2999(75)90061-8

Nature of neuronal uptake and noradrenaline-adrenaline effects in the isolated rat vas deferens

Jesús A. Garcia-Sevilla, Albert Badia, Josep Laporte

Department of Pharmacology, Therapeutics and Toxicology

Research output: Contribution to journal › Article › Research › peer-review

Abstract

Uptake mechanisms in the rat vas deferens have not yet been thoroughly investigated. In this study we show that uptake inhibition by cocaine, amantadine and desmethylimipramine induces increases in sensitivity that are greater for adrenaline than for noradrenaline. However, this does not occur when guanethidine is used. These results are clearly in disagreement with the neuronal uptake hypothesis. Uptake mechanisms in the rat vas deferens may be different from those of other tissues. © 1975.

Original language	English
Pages (from-to)	363-366
Journal	European Journal of Pharmacology
Volume	31
Issue number	2
DOIs	https://doi.org/10.1016/0014-2999(75)90061-8
Publication status	Published - 1 Jan 1975

Keywords

Adrenaline
Noradrenaline
Uptake inhibitors
Vas deferens, rat

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title = "Nature of neuronal uptake and noradrenaline-adrenaline effects in the isolated rat vas deferens",

abstract = "Uptake mechanisms in the rat vas deferens have not yet been thoroughly investigated. In this study we show that uptake inhibition by cocaine, amantadine and desmethylimipramine induces increases in sensitivity that are greater for adrenaline than for noradrenaline. However, this does not occur when guanethidine is used. These results are clearly in disagreement with the neuronal uptake hypothesis. Uptake mechanisms in the rat vas deferens may be different from those of other tissues. {\textcopyright} 1975.",

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N2 - Uptake mechanisms in the rat vas deferens have not yet been thoroughly investigated. In this study we show that uptake inhibition by cocaine, amantadine and desmethylimipramine induces increases in sensitivity that are greater for adrenaline than for noradrenaline. However, this does not occur when guanethidine is used. These results are clearly in disagreement with the neuronal uptake hypothesis. Uptake mechanisms in the rat vas deferens may be different from those of other tissues. © 1975.

AB - Uptake mechanisms in the rat vas deferens have not yet been thoroughly investigated. In this study we show that uptake inhibition by cocaine, amantadine and desmethylimipramine induces increases in sensitivity that are greater for adrenaline than for noradrenaline. However, this does not occur when guanethidine is used. These results are clearly in disagreement with the neuronal uptake hypothesis. Uptake mechanisms in the rat vas deferens may be different from those of other tissues. © 1975.

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KW - Noradrenaline

KW - Uptake inhibitors

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