Naturally occurring NS3-protease-inhibitor resistant mutant A156T in the liver of an untreated chronic hepatitis C patient

Maria Cubero, Juan Ignacio Esteban, Teresa Otero, Silvia Sauleda, Marta Bes, Rafael Esteban, Jaume Guardia, Josep Quer

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Abstract

An increasing number of new hepatitis C virus NS3-protease inhibitors are being evaluated for the treatment of chronic hepatitis C. Treatment-induced selection of mutants conferring resistance to protease inhibitors has been shown both in vivo and in vitro. A specific mutation, A156T has been shown to confer high-level resistance to several such agents (BILN2061, VX-950, SCH446211 (SCH6) and SCH503034). Here we report the presence of the A156T mutation in close to 1% of NS3 sequences within the liver quasispecies of a chronic hepatitis C patient never treated with anti-NS3-protease inhibitors. © 2007 Elsevier Inc. All rights reserved.
Original languageEnglish
Pages (from-to)237-245
JournalVirology
Volume370
Issue number2
DOIs
Publication statusPublished - 20 Jan 2008

Keywords

  • HCV-NS3
  • Inhibitor
  • Mutant
  • Patient
  • Resistant
  • Untreated

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