An increasing number of new hepatitis C virus NS3-protease inhibitors are being evaluated for the treatment of chronic hepatitis C. Treatment-induced selection of mutants conferring resistance to protease inhibitors has been shown both in vivo and in vitro. A specific mutation, A156T has been shown to confer high-level resistance to several such agents (BILN2061, VX-950, SCH446211 (SCH6) and SCH503034). Here we report the presence of the A156T mutation in close to 1% of NS3 sequences within the liver quasispecies of a chronic hepatitis C patient never treated with anti-NS3-protease inhibitors. © 2007 Elsevier Inc. All rights reserved.
Cubero, M., Esteban, J. I., Otero, T., Sauleda, S., Bes, M., Esteban, R., Guardia, J., & Quer, J. (2008). Naturally occurring NS3-protease-inhibitor resistant mutant A156T in the liver of an untreated chronic hepatitis C patient. Virology, 370(2), 237-245. https://doi.org/10.1016/j.virol.2007.10.006