Native valve endocarditis due to Candida glabrata treated without valvular replacement: a potential role for caspofungin in the induction and maintenance treatment.

M. J. Jiménez-Expósito*, G. Torres, A. Baraldés, N. Benito, F. Marco, J. C. Paré, A. Moreno, X. Claramonte, C. A. Mestres, M. Almela, C. García de la María, N. Pérez, W. A. Schell, G. R. Corey, J. Perfect, M. T. Jiménez de Anta, J. M. Gatell, J. M. Miró

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Abstract

Conventional antifungal therapy for fungal endocarditis has been associated with a poor cure rate. Therefore, combined medical and surgical therapy has been recommended. However, new potent antifungal agents, such as echinocandins, could increase the medical options and, in some cases, avoid the need for surgery. We report a case of Candida endocarditis treated successfully without valve replacement with intravenous liposomal amphotericin B (total dose, 4 g) and intravenous caspofungin (a 100-mg loading dose followed by 50 mg per day for 8 weeks) as induction therapy and intravenous caspofungin (100 mg 3 times per week for 12 weeks) as maintenance therapy.

Original languageEnglish
Pages (from-to)e70-73
JournalClinical Infectious Diseases
Volume39
Issue number7
DOIs
Publication statusPublished - 1 Oct 2004

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