Nano/Micro formulations for bacteriophage delivery

Pilar Cortés, Mary Cano-Sarabia, Joan Colom, Jennifer Otero, Daniel Maspoch, Montserrat Llagostera

Research output: Chapter in BookChapterResearchpeer-review

6 Citations (Scopus)

Abstract

© Springer Science+Business Media LLC 2018. Encapsulation methodologies allow the protection of bacteriophages for overcoming critical environmental conditions. Moreover, they improve the stability and the controlled delivery of bacteriophages which is of great innovative value in bacteriophage therapy. Here, two different encapsulation methodologies of bacteriophages are described using two biocompatible materials: a lipid cationic mixture and a combination of alginate with the antacid CaCO3. To perform bacteriophage encapsulation, a purified lysate highly concentrated (around 1010–1011 pfu/mL) is necessary, and to dispose of a specific equipment. Both methodologies have been successfully applied for encapsulating Salmonella bacteriophages with different morphologies. Also, the material employed does not modify the antibacterial action of bacteriophages. Moreover, both technologies can also be adapted to any bacteriophage and possibly to any delivery route for bacteriophage therapy.
Original languageEnglish
Title of host publicationBacteriophage Therapy. Methods in Molecular Biology
Place of PublicationNova York (US)
Pages271-283
Number of pages12
Volume1693
Edition1
DOIs
Publication statusPublished - 1 Jan 2018

Publication series

NameSpringer Protocols

Keywords

  • Alginate
  • Bacteriophages
  • Liposomes
  • Microparticles
  • Nanoparticles

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