Abstract
© 2019 Elsevier B.V. N-Alkylated-α-amino acids are useful building blocks for the pharmaceutical and fine chemical industries. Enantioselective methods of N-alkylated-α-amino acid synthesis are therefore highly valuable and widely investigated. While there are a variety of chemical methods for their synthesis, they often employ stoichiometric quantities of hazardous reagents such as pyrophoric metal hydrides or genotoxic alkylating agents, whereas biocatalytic routes can provide a greener and cleaner alternative to existing methods. This review highlights the occurrence of the N-alkyl-α-amino acid motif and its role in nature, important applications towards human health and biocatalytic methods of preparation. Several enzyme classes that can be used to access chiral N-alkylated-α-amino acids and their substrate selectivities are detailed.
Original language | English |
---|---|
Pages (from-to) | 56-65 |
Number of pages | 10 |
Journal | Journal of Biotechnology |
Volume | 293 |
DOIs | |
Publication status | Published - 10 Mar 2019 |
Keywords
- Biocatalysis
- Dehydrogenases
- N-Alkyl-α-amino acids
- N-Methyl transferases
- Nature
- Animals
- Humans
- Amino Acids/biosynthesis
- PROTEIN METHYLATION
- PSEUDOMONAS-PUTIDA
- N-Alkyl-alpha-amino acids
- ENZYMATIC-SYNTHESIS
- PHENYLALANINE AMMONIA-LYASE
- PYRROLINE-5-CARBOXYLATE REDUCTASE
- SUBSTITUTED ASPARTIC ACIDS
- ENANTIOSELECTIVE REDUCTIVE AMINATION
- OPINE DEHYDROGENASE
- OCTOPINE DEHYDROGENASE
- IMINE REDUCTASES