Myoglobin RIA in detecting carriers of duchenne’s muscular dystrophy

M. Sabria-Leal; J. M. Gimeno-Leal; A. Paret-Masana; C. Rey Joly Barroso

doi:10.1159/000116017

Myoglobin RIA in detecting carriers of duchenne’s muscular dystrophy

M. Sabria-Leal, J. M. Gimeno-Leal, A. Paret-Masana, C. Rey Joly Barroso

Department of Medicine

Research output: Contribution to journal › Article › Research › peer-review

3 Citations (Scopus)

Abstract

In a prospective study we evaluated myoglobin (MG) and serum creatine kinase (CK) levels in two groups of subjects different in age and carrier status. CK and MG values were significantly lower in the older group. Whereas both parameters fully coincided in the younger group, CK was detected in a higher number of carriers in the older group. MG was always kept within the limits of normality when CK values were normal. We conclude that (a) simultaneous determination of CK and MG does not improve carrier detection rate, (b) the behavior of both biological parameters is similar in the younger age. and CK is more effective than MG for this purpose in the older subjects. © 1986 S. Karger AG, Basel.

Original language	English
Pages (from-to)	253-255
Journal	European Neurology
Volume	25
Issue number	4
DOIs	https://doi.org/10.1159/000116017
Publication status	Published - 1 Jan 1986

Keywords

Carrier detection
Creatine kinase
Duchenne’s dystrophy
Neuromuscular disease
Serum myoglobin

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title = "Myoglobin RIA in detecting carriers of duchenne{\textquoteright}s muscular dystrophy",

abstract = "In a prospective study we evaluated myoglobin (MG) and serum creatine kinase (CK) levels in two groups of subjects different in age and carrier status. CK and MG values were significantly lower in the older group. Whereas both parameters fully coincided in the younger group, CK was detected in a higher number of carriers in the older group. MG was always kept within the limits of normality when CK values were normal. We conclude that (a) simultaneous determination of CK and MG does not improve carrier detection rate, (b) the behavior of both biological parameters is similar in the younger age. and CK is more effective than MG for this purpose in the older subjects. {\textcopyright} 1986 S. Karger AG, Basel.",

keywords = "Carrier detection, Creatine kinase, Duchenne{\textquoteright}s dystrophy, Neuromuscular disease, Serum myoglobin",

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doi = "10.1159/000116017",

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AU - Sabria-Leal, M.

AU - Gimeno-Leal, J. M.

AU - Paret-Masana, A.

AU - Barroso, C. Rey Joly

PY - 1986/1/1

Y1 - 1986/1/1

N2 - In a prospective study we evaluated myoglobin (MG) and serum creatine kinase (CK) levels in two groups of subjects different in age and carrier status. CK and MG values were significantly lower in the older group. Whereas both parameters fully coincided in the younger group, CK was detected in a higher number of carriers in the older group. MG was always kept within the limits of normality when CK values were normal. We conclude that (a) simultaneous determination of CK and MG does not improve carrier detection rate, (b) the behavior of both biological parameters is similar in the younger age. and CK is more effective than MG for this purpose in the older subjects. © 1986 S. Karger AG, Basel.

AB - In a prospective study we evaluated myoglobin (MG) and serum creatine kinase (CK) levels in two groups of subjects different in age and carrier status. CK and MG values were significantly lower in the older group. Whereas both parameters fully coincided in the younger group, CK was detected in a higher number of carriers in the older group. MG was always kept within the limits of normality when CK values were normal. We conclude that (a) simultaneous determination of CK and MG does not improve carrier detection rate, (b) the behavior of both biological parameters is similar in the younger age. and CK is more effective than MG for this purpose in the older subjects. © 1986 S. Karger AG, Basel.

KW - Carrier detection

KW - Creatine kinase

KW - Duchenne’s dystrophy

KW - Neuromuscular disease

KW - Serum myoglobin

U2 - 10.1159/000116017

DO - 10.1159/000116017

M3 - Article

SN - 0014-3022

VL - 25

SP - 253

EP - 255

JO - European Neurology

JF - European Neurology

IS - 4

ER -

Myoglobin RIA in detecting carriers of duchenne’s muscular dystrophy

Abstract

Keywords

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