TY - JOUR
T1 - Myeloid cell responses after spinal cord injury
AU - David, Samuel
AU - Kroner, Antje
AU - Greenhalgh, Andrew D.
AU - Zarruk, Juan G.
AU - López-Vales, Rubén
PY - 2018/8/15
Y1 - 2018/8/15
N2 - © 2018 The past decade has revealed much about the complexity of the local inflammatory response after spinal cord injury (SCI). A major challenge is to distinguish between microglia and monocyte-derived macrophages (MDMs) to determine their phenotype and function. Transcriptome studies have revealed microglia-selective genes but are still limited in scope because many markers are downregulated after injury. Additionally, new genetic reporter mice are available to study microglia and MDMs. There is more evidence now for the plasticity and heterogeneity of microglia and MDMs. We also discuss the role of neutrophils that are the first peripheral cells to enter the injured CNS.
AB - © 2018 The past decade has revealed much about the complexity of the local inflammatory response after spinal cord injury (SCI). A major challenge is to distinguish between microglia and monocyte-derived macrophages (MDMs) to determine their phenotype and function. Transcriptome studies have revealed microglia-selective genes but are still limited in scope because many markers are downregulated after injury. Additionally, new genetic reporter mice are available to study microglia and MDMs. There is more evidence now for the plasticity and heterogeneity of microglia and MDMs. We also discuss the role of neutrophils that are the first peripheral cells to enter the injured CNS.
U2 - 10.1016/j.jneuroim.2018.06.003
DO - 10.1016/j.jneuroim.2018.06.003
M3 - Review article
C2 - 29957394
SN - 0165-5728
VL - 321
SP - 97
EP - 108
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
ER -