Myelin Oligodendrocyte Glycoprotein Antibodies in Adults with a First Demyelinating Event Suggestive of Multiple Sclerosis

Javier Villacieros-Álvarez; Carmen Espejo; Georgina Arrambide; Mireia Castillo; Pere Carbonell-Mirabent; Marta Rodriguez; Luca Bollo; Joaquín Castilló; Manuel Comabella; Ingrid Galán; Luciana Midaglia; Neus Mongay; Carlos Nos; Jordi Rio; Breogan Rodríguez-Acevedo; Jaume Sastre-Garriga; Carmen Tur; Angela Vidal-Jordana; Andreu Vilaseca; Ana Zabalza; Cristina Auger; Alex Rovira; Xavier Montalban; Mar Tintoré; Álvaro Cobo-Calvo

doi:10.1002/ana.26793

Myelin Oligodendrocyte Glycoprotein Antibodies in Adults with a First Demyelinating Event Suggestive of Multiple Sclerosis

Javier Villacieros-Álvarez, Carmen Espejo, Georgina Arrambide, Mireia Castillo, Pere Carbonell-Mirabent, Marta Rodriguez, Luca Bollo, Joaquín Castilló, Manuel Comabella, Ingrid Galán, Luciana Midaglia, Neus Mongay, Carlos Nos, Jordi Rio, Breogan Rodríguez-Acevedo, Jaume Sastre-Garriga, Carmen Tur, Angela Vidal-Jordana, Andreu Vilaseca, Ana ZabalzaCristina Auger, Alex Rovira, Xavier Montalban, Mar Tintoré, Álvaro Cobo-Calvo

Department of Medicine

Research output: Contribution to journal › Article › Research › peer-review

5 Citations (Web of Science)

Abstract

OBJECTIVE: Myelin oligodendrocyte glycoprotein antibodies (MOG-Ab) distinguish multiple sclerosis (MS) from MOG-associated disease in most cases. However, studies analyzing MOG-Ab at the time of a first demyelinating event suggestive of MS in adults are lacking. We aimed to (1) evaluate the prevalence of MOG-Ab in a first demyelinating event suggestive of MS and (2) compare clinical and paraclinical features between seropositive (MOG-Ab+) and seronegative (MOG-Ab-) patients.

METHODS: Six hundred thirty adult patients with available serum samples obtained within 6 months from the first event were included. MOG-Ab were analyzed using a live cell-based assay. Statistical analyses included parametric and nonparametric tests, logistic regression, and survival models.

RESULTS: MOG-Ab were positive in 17 of 630 (2.7%). Fourteen out of 17 (82.4%) MOG-Ab+ patients presented with optic neuritis (ON) compared to 227of 613 (37.0%) MOG-Ab- patients (p = 0.009). Cerebrospinal fluid-restricted oligoclonal bands (CSF-OBs) were found in 2 of 16 (12.5%) MOG-Ab+ versus 371 of 601 (61.7%) MOG-Ab- subjects (p < 0.001). Baseline brain magnetic resonance imaging (MRI) was normal in 9 of 17 (52.9%) MOG-Ab+ versus 153 of 585 (26.2%) MOG-Ab- patients (p = 0.029). Absence of CSF-OBs and ON at onset were independently associated with MOG-Ab positivity (odds ratio [OR] = 9.03, 95% confidence interval [CI] = 2.04-53.6, p = 0.009; and OR = 4.17, 95% CI = 1.15-19.8, p = 0.042, respectively). Of MOG-Ab+ patients, 22.9% (95% CI = 0.0-42.7) compared to 67.6% (95% CI = 63.3-71.3) of MOG-Ab- patients fulfilled McDonald 2017 criteria at 5 years (log-rank p = 0.003).

INTERPRETATION: MOG-Ab are infrequent in adults with a first demyelinating event suggestive of MS. However, based on our results, we suggest to determine these antibodies in those patients with ON and absence of CSF-OBs, as long as the brain MRI is not suggestive of MS. ANN NEUROL 2023.

Original language	English
Pages (from-to)	116-128
Number of pages	13
Journal	Annals of Neurology
Volume	95
Issue number	1
Early online date	14 Sept 2023
DOIs	https://doi.org/10.1002/ana.26793
Publication status	Published - Jan 2024

Keywords

Disease
Mog
Neuromyelitis-optica
Spectrum

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Villacieros-Álvarez, J., Espejo, C., Arrambide, G., Castillo, M., Carbonell-Mirabent, P., Rodriguez, M., Bollo, L., Castilló, J., Comabella, M., Galán, I., Midaglia, L., Mongay, N., Nos, C., Rio, J., Rodríguez-Acevedo, B., Sastre-Garriga, J., Tur, C., Vidal-Jordana, A., Vilaseca, A., ... Cobo-Calvo, Á. (2024). Myelin Oligodendrocyte Glycoprotein Antibodies in Adults with a First Demyelinating Event Suggestive of Multiple Sclerosis. Annals of Neurology, 95(1), 116-128. https://doi.org/10.1002/ana.26793

@article{1fe7ca65fe724bdc928ca3fddf86a441,

title = "Myelin Oligodendrocyte Glycoprotein Antibodies in Adults with a First Demyelinating Event Suggestive of Multiple Sclerosis",

abstract = "OBJECTIVE: Myelin oligodendrocyte glycoprotein antibodies (MOG-Ab) distinguish multiple sclerosis (MS) from MOG-associated disease in most cases. However, studies analyzing MOG-Ab at the time of a first demyelinating event suggestive of MS in adults are lacking. We aimed to (1) evaluate the prevalence of MOG-Ab in a first demyelinating event suggestive of MS and (2) compare clinical and paraclinical features between seropositive (MOG-Ab+) and seronegative (MOG-Ab-) patients.METHODS: Six hundred thirty adult patients with available serum samples obtained within 6 months from the first event were included. MOG-Ab were analyzed using a live cell-based assay. Statistical analyses included parametric and nonparametric tests, logistic regression, and survival models.RESULTS: MOG-Ab were positive in 17 of 630 (2.7%). Fourteen out of 17 (82.4%) MOG-Ab+ patients presented with optic neuritis (ON) compared to 227of 613 (37.0%) MOG-Ab- patients (p = 0.009). Cerebrospinal fluid-restricted oligoclonal bands (CSF-OBs) were found in 2 of 16 (12.5%) MOG-Ab+ versus 371 of 601 (61.7%) MOG-Ab- subjects (p < 0.001). Baseline brain magnetic resonance imaging (MRI) was normal in 9 of 17 (52.9%) MOG-Ab+ versus 153 of 585 (26.2%) MOG-Ab- patients (p = 0.029). Absence of CSF-OBs and ON at onset were independently associated with MOG-Ab positivity (odds ratio [OR] = 9.03, 95% confidence interval [CI] = 2.04-53.6, p = 0.009; and OR = 4.17, 95% CI = 1.15-19.8, p = 0.042, respectively). Of MOG-Ab+ patients, 22.9% (95% CI = 0.0-42.7) compared to 67.6% (95% CI = 63.3-71.3) of MOG-Ab- patients fulfilled McDonald 2017 criteria at 5 years (log-rank p = 0.003).INTERPRETATION: MOG-Ab are infrequent in adults with a first demyelinating event suggestive of MS. However, based on our results, we suggest to determine these antibodies in those patients with ON and absence of CSF-OBs, as long as the brain MRI is not suggestive of MS. ANN NEUROL 2023.",

keywords = "Disease, Mog, Neuromyelitis-optica, Spectrum",

author = "Javier Villacieros-{\'A}lvarez and Carmen Espejo and Georgina Arrambide and Mireia Castillo and Pere Carbonell-Mirabent and Marta Rodriguez and Luca Bollo and Joaqu{\'i}n Castill{\'o} and Manuel Comabella and Ingrid Gal{\'a}n and Luciana Midaglia and Neus Mongay and Carlos Nos and Jordi Rio and Breogan Rodr{\'i}guez-Acevedo and Jaume Sastre-Garriga and Carmen Tur and Angela Vidal-Jordana and Andreu Vilaseca and Ana Zabalza and Cristina Auger and Alex Rovira and Xavier Montalban and Mar Tintor{\'e} and {\'A}lvaro Cobo-Calvo",

note = "{\textcopyright} 2023 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.",

year = "2024",

month = jan,

doi = "10.1002/ana.26793",

language = "English",

volume = "95",

pages = "116--128",

journal = "Annals of Neurology",

issn = "0364-5134",

publisher = "John Wiley and Sons Inc.",

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Villacieros-Álvarez, J, Espejo, C, Arrambide, G, Castillo, M, Carbonell-Mirabent, P, Rodriguez, M, Bollo, L, Castilló, J, Comabella, M, Galán, I, Midaglia, L, Mongay, N, Nos, C, Rio, J, Rodríguez-Acevedo, B, Sastre-Garriga, J, Tur, C, Vidal-Jordana, A, Vilaseca, A, Zabalza, A, Auger, C, Rovira, A, Montalban, X, Tintoré, M & Cobo-Calvo, Á 2024, 'Myelin Oligodendrocyte Glycoprotein Antibodies in Adults with a First Demyelinating Event Suggestive of Multiple Sclerosis', Annals of Neurology, vol. 95, no. 1, pp. 116-128. https://doi.org/10.1002/ana.26793

TY - JOUR

T1 - Myelin Oligodendrocyte Glycoprotein Antibodies in Adults with a First Demyelinating Event Suggestive of Multiple Sclerosis

AU - Villacieros-Álvarez, Javier

AU - Espejo, Carmen

AU - Arrambide, Georgina

AU - Castillo, Mireia

AU - Carbonell-Mirabent, Pere

AU - Rodriguez, Marta

AU - Bollo, Luca

AU - Castilló, Joaquín

AU - Comabella, Manuel

AU - Galán, Ingrid

AU - Midaglia, Luciana

AU - Mongay, Neus

AU - Nos, Carlos

AU - Rio, Jordi

AU - Rodríguez-Acevedo, Breogan

AU - Sastre-Garriga, Jaume

AU - Tur, Carmen

AU - Vidal-Jordana, Angela

AU - Vilaseca, Andreu

AU - Zabalza, Ana

AU - Auger, Cristina

AU - Rovira, Alex

AU - Montalban, Xavier

AU - Tintoré, Mar

AU - Cobo-Calvo, Álvaro

PY - 2024/1

Y1 - 2024/1

N2 - OBJECTIVE: Myelin oligodendrocyte glycoprotein antibodies (MOG-Ab) distinguish multiple sclerosis (MS) from MOG-associated disease in most cases. However, studies analyzing MOG-Ab at the time of a first demyelinating event suggestive of MS in adults are lacking. We aimed to (1) evaluate the prevalence of MOG-Ab in a first demyelinating event suggestive of MS and (2) compare clinical and paraclinical features between seropositive (MOG-Ab+) and seronegative (MOG-Ab-) patients.METHODS: Six hundred thirty adult patients with available serum samples obtained within 6 months from the first event were included. MOG-Ab were analyzed using a live cell-based assay. Statistical analyses included parametric and nonparametric tests, logistic regression, and survival models.RESULTS: MOG-Ab were positive in 17 of 630 (2.7%). Fourteen out of 17 (82.4%) MOG-Ab+ patients presented with optic neuritis (ON) compared to 227of 613 (37.0%) MOG-Ab- patients (p = 0.009). Cerebrospinal fluid-restricted oligoclonal bands (CSF-OBs) were found in 2 of 16 (12.5%) MOG-Ab+ versus 371 of 601 (61.7%) MOG-Ab- subjects (p < 0.001). Baseline brain magnetic resonance imaging (MRI) was normal in 9 of 17 (52.9%) MOG-Ab+ versus 153 of 585 (26.2%) MOG-Ab- patients (p = 0.029). Absence of CSF-OBs and ON at onset were independently associated with MOG-Ab positivity (odds ratio [OR] = 9.03, 95% confidence interval [CI] = 2.04-53.6, p = 0.009; and OR = 4.17, 95% CI = 1.15-19.8, p = 0.042, respectively). Of MOG-Ab+ patients, 22.9% (95% CI = 0.0-42.7) compared to 67.6% (95% CI = 63.3-71.3) of MOG-Ab- patients fulfilled McDonald 2017 criteria at 5 years (log-rank p = 0.003).INTERPRETATION: MOG-Ab are infrequent in adults with a first demyelinating event suggestive of MS. However, based on our results, we suggest to determine these antibodies in those patients with ON and absence of CSF-OBs, as long as the brain MRI is not suggestive of MS. ANN NEUROL 2023.

AB - OBJECTIVE: Myelin oligodendrocyte glycoprotein antibodies (MOG-Ab) distinguish multiple sclerosis (MS) from MOG-associated disease in most cases. However, studies analyzing MOG-Ab at the time of a first demyelinating event suggestive of MS in adults are lacking. We aimed to (1) evaluate the prevalence of MOG-Ab in a first demyelinating event suggestive of MS and (2) compare clinical and paraclinical features between seropositive (MOG-Ab+) and seronegative (MOG-Ab-) patients.METHODS: Six hundred thirty adult patients with available serum samples obtained within 6 months from the first event were included. MOG-Ab were analyzed using a live cell-based assay. Statistical analyses included parametric and nonparametric tests, logistic regression, and survival models.RESULTS: MOG-Ab were positive in 17 of 630 (2.7%). Fourteen out of 17 (82.4%) MOG-Ab+ patients presented with optic neuritis (ON) compared to 227of 613 (37.0%) MOG-Ab- patients (p = 0.009). Cerebrospinal fluid-restricted oligoclonal bands (CSF-OBs) were found in 2 of 16 (12.5%) MOG-Ab+ versus 371 of 601 (61.7%) MOG-Ab- subjects (p < 0.001). Baseline brain magnetic resonance imaging (MRI) was normal in 9 of 17 (52.9%) MOG-Ab+ versus 153 of 585 (26.2%) MOG-Ab- patients (p = 0.029). Absence of CSF-OBs and ON at onset were independently associated with MOG-Ab positivity (odds ratio [OR] = 9.03, 95% confidence interval [CI] = 2.04-53.6, p = 0.009; and OR = 4.17, 95% CI = 1.15-19.8, p = 0.042, respectively). Of MOG-Ab+ patients, 22.9% (95% CI = 0.0-42.7) compared to 67.6% (95% CI = 63.3-71.3) of MOG-Ab- patients fulfilled McDonald 2017 criteria at 5 years (log-rank p = 0.003).INTERPRETATION: MOG-Ab are infrequent in adults with a first demyelinating event suggestive of MS. However, based on our results, we suggest to determine these antibodies in those patients with ON and absence of CSF-OBs, as long as the brain MRI is not suggestive of MS. ANN NEUROL 2023.

KW - Disease

KW - Mog

KW - Neuromyelitis-optica

KW - Spectrum

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U2 - 10.1002/ana.26793

DO - 10.1002/ana.26793

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SN - 0364-5134

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JO - Annals of Neurology

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Myelin Oligodendrocyte Glycoprotein Antibodies in Adults with a First Demyelinating Event Suggestive of Multiple Sclerosis

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