Mycoplasma genitalium adhesin P110 binds sialic-acid human receptors

David Aparicio, Sergi Torres-Puig, Mercè Ratera, Enrique Querol, Jaume Piñol, Oscar Q. Pich, Ignacio Fita

Research output: Contribution to journalArticleResearch

12 Citations (Scopus)

Abstract

© 2018, The Author(s). Adhesion of pathogenic bacteria to target cells is a prerequisite for colonization and further infection. The main adhesins of the emerging sexually transmitted pathogen Mycoplasma genitalium, P140 and P110, interact to form a Nap complex anchored to the cell membrane. Herein, we present the crystal structures of the extracellular region of the virulence factor P110 (916 residues) unliganded and in complex with sialic acid oligosaccharides. P110 interacts only with the neuraminic acid moiety of the oligosaccharides and experiments with human cells demonstrate that these interactions are essential for mycoplasma cytadherence. Additionally, structural information provides a deep insight of the P110 antigenic regions undergoing programmed variation to evade the host immune response. These results enlighten the interplay of M. genitalium with human target cells, offering new strategies to control mycoplasma infections.
Original languageEnglish
Article number4471
JournalNature Communications
Volume9
DOIs
Publication statusPublished - 1 Dec 2018

Fingerprint Dive into the research topics of 'Mycoplasma genitalium adhesin P110 binds sialic-acid human receptors'. Together they form a unique fingerprint.

Cite this