Mycobacterium africanum, an emerging disease in high-income countries?

M. C. Isea-Peña, M. F. Brezmes-Valdivieso, M. C. González-Velasco, M. A. Lezcano-Carrera, L. López-Urrutia-Lorente, N. Martín-Casabona, M. L. Monforte-Cirac, J. J. Palacios, A. Penedo-Pallares, A. Ramirez-Rosales, R. Sánchez-Silos, T. Tórtola-Fernández, J. Viñuelas-Bayón, A. Vitoria-Agreda, M. I. Blanco, L. Barreiro, H. Villar, A. Torreblanca, E. Hidalgo, J. Diaz-GiganteF. Hidalgo, S. Calzón, Jaime Esteban

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    12 Citations (Scopus)

    Abstract

    BACKGROUND: Mycobacterium africanum is a cause of tuberculosis (TB) that has mainly been described in Africa, but immigration and travel patterns have contributed to the spread of the disease to other countries. METHODS: We retrospectively reviewed TB cases due to M. africanum during 2000-2010 in seven Spanish hospitals. Selected clinical charts were reviewed using a predefined protocol that included demographical, clinical and microbiological data and outcome. RESULTS: Although 57 cases were diagnosed, only 36 clinical charts were available for review: 82.8% were men and the mean age was 31.6 years (range 12-81). Forty-four cases were from Africa, 1 from the Philippines, 1 from India, and 4 from Spain, while the country of origin was unknown in 7 cases. The most frequent site of infection was the lung (58.3%). Four cases (6.9%) were resistant to at least one first-line anti-tuberculosis drug. CONCLUSIONS: Disease due to M. africanum in industrialised countries is mainly associated with immigration from endemic areas, although some cases also occur among native-born populations. © 2012 The Union.
    Original languageEnglish
    Pages (from-to)1400-1404
    JournalInternational Journal of Tuberculosis and Lung Disease
    Volume16
    Issue number10
    DOIs
    Publication statusPublished - 1 Oct 2012

    Keywords

    • High-income
    • Mycobacterium africanum
    • Tuberculosis

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    Isea-Peña, M. C., Brezmes-Valdivieso, M. F., González-Velasco, M. C., Lezcano-Carrera, M. A., López-Urrutia-Lorente, L., Martín-Casabona, N., Monforte-Cirac, M. L., Palacios, J. J., Penedo-Pallares, A., Ramirez-Rosales, A., Sánchez-Silos, R., Tórtola-Fernández, T., Viñuelas-Bayón, J., Vitoria-Agreda, A., Blanco, M. I., Barreiro, L., Villar, H., Torreblanca, A., Hidalgo, E., ... Esteban, J. (2012). Mycobacterium africanum, an emerging disease in high-income countries? International Journal of Tuberculosis and Lung Disease, 16(10), 1400-1404. https://doi.org/10.5588/ijtld.12.0142