TY - JOUR
T1 - MYC Inhibition Halts Metastatic Breast Cancer Progression by Blocking Growth, Invasion, and Seeding
AU - Massó Vallés, Daniel
AU - Beaulieu, Marie-Eve
AU - Jauset González, Toni
AU - Giuntini, Fabio
AU - Zacarías-Fluck, Mariano F
AU - Foradada, Laia
AU - Martínez-Martín, Sandra
AU - Serrano, Erika
AU - Martín-Fernández, Génesis
AU - Casacuberta-Serra, Sílvia
AU - Castillo Cano, Virginia
AU - Kaur, Jastrinjan
AU - López-Estévez, Sergio
AU - Morcillo, Miguel Ángel
AU - Alzrigat, Mohammad
AU - Mahmoud, Loay
AU - Luque-García, Antonio
AU - Escorihuela, Marta
AU - Guzman, Marta
AU - Arribas, Joaquín V
AU - Serra, Violeta
AU - Larsson, Lars-Gunnar
AU - Whitfield, Jonathan R.
AU - Soucek, Laura
PY - 2022
Y1 - 2022
N2 - While MYC role in metastasis has been long controversial, this manuscript demonstrates that MYC inhibition by either transgenic expression or pharmacologic use of the recombinantly produced Omomyc miniprotein exerts antitumor and antimetastatic activity in breast cancer models in vitro and in vivo, suggesting its clinical applicability.
AB - While MYC role in metastasis has been long controversial, this manuscript demonstrates that MYC inhibition by either transgenic expression or pharmacologic use of the recombinantly produced Omomyc miniprotein exerts antitumor and antimetastatic activity in breast cancer models in vitro and in vivo, suggesting its clinical applicability.
U2 - 10.1158/2767-9764.CRC-21-0103
DO - 10.1158/2767-9764.CRC-21-0103
M3 - Article
C2 - 36860495
SN - 2767-9764
VL - 2
SP - 110
EP - 130
JO - Cancer Research Communications
JF - Cancer Research Communications
ER -
