Mutations in the quinolone-resistance determining region (QRDR) of Salmonella strains isolated from pigs in Spain

C. Seminati; W. Mejia; E. Mateu; M. Martin

doi:https://doi.org/10.1016/j.vetmic.2004.12.024

Mutations in the quinolone-resistance determining region (QRDR) of Salmonella strains isolated from pigs in Spain

C. Seminati, W. Mejia, E. Mateu, M. Martin

Department of Animal Health and Anatomy

Research output: Contribution to journal › Article › Research › peer-review

6 Citations (Scopus)

Abstract

Quinolone-resistance determining region (QRDR) of Gyrase A gene was sequenced in 54 Salmonella strains of pig origin that have different quinolone-resistance patterns. Those strains accounted for 12 different serotypes. Mutations at Ser83 or Asp87 were predominant in the studied isolates. However, for serotypes Anatum and Virchow, resistance to quinolones seemed to be linked to specific mutations, namely, Ser83 → Tyr and Ser83 → Phe, respectively. Other mutations found in different positions did not seem to have clinical significance except for changes at Asp82. © 2005 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	297-301
Journal	Veterinary Microbiology
Volume	106
DOIs	https://doi.org/10.1016/j.vetmic.2004.12.024
Publication status	Published - 10 Apr 2005

Keywords

Pig
QRDR
Quinolone
Resistance
Salmonella

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https://doi.org/10.1016/j.vetmic.2004.12.024

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title = "Mutations in the quinolone-resistance determining region (QRDR) of Salmonella strains isolated from pigs in Spain",

abstract = "Quinolone-resistance determining region (QRDR) of Gyrase A gene was sequenced in 54 Salmonella strains of pig origin that have different quinolone-resistance patterns. Those strains accounted for 12 different serotypes. Mutations at Ser83 or Asp87 were predominant in the studied isolates. However, for serotypes Anatum and Virchow, resistance to quinolones seemed to be linked to specific mutations, namely, Ser83 → Tyr and Ser83 → Phe, respectively. Other mutations found in different positions did not seem to have clinical significance except for changes at Asp82. {\textcopyright} 2005 Elsevier B.V. All rights reserved.",

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doi = "https://doi.org/10.1016/j.vetmic.2004.12.024",

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T1 - Mutations in the quinolone-resistance determining region (QRDR) of Salmonella strains isolated from pigs in Spain

AU - Seminati, C.

AU - Mejia, W.

AU - Mateu, E.

AU - Martin, M.

PY - 2005/4/10

Y1 - 2005/4/10

N2 - Quinolone-resistance determining region (QRDR) of Gyrase A gene was sequenced in 54 Salmonella strains of pig origin that have different quinolone-resistance patterns. Those strains accounted for 12 different serotypes. Mutations at Ser83 or Asp87 were predominant in the studied isolates. However, for serotypes Anatum and Virchow, resistance to quinolones seemed to be linked to specific mutations, namely, Ser83 → Tyr and Ser83 → Phe, respectively. Other mutations found in different positions did not seem to have clinical significance except for changes at Asp82. © 2005 Elsevier B.V. All rights reserved.

AB - Quinolone-resistance determining region (QRDR) of Gyrase A gene was sequenced in 54 Salmonella strains of pig origin that have different quinolone-resistance patterns. Those strains accounted for 12 different serotypes. Mutations at Ser83 or Asp87 were predominant in the studied isolates. However, for serotypes Anatum and Virchow, resistance to quinolones seemed to be linked to specific mutations, namely, Ser83 → Tyr and Ser83 → Phe, respectively. Other mutations found in different positions did not seem to have clinical significance except for changes at Asp82. © 2005 Elsevier B.V. All rights reserved.

KW - Pig

KW - QRDR

KW - Quinolone

KW - Resistance

KW - Salmonella

U2 - https://doi.org/10.1016/j.vetmic.2004.12.024

DO - https://doi.org/10.1016/j.vetmic.2004.12.024

M3 - Article

VL - 106

SP - 297

EP - 301

JO - Veterinary Microbiology

JF - Veterinary Microbiology

SN - 0378-1135

ER -

Mutations in the quinolone-resistance determining region (QRDR) of Salmonella strains isolated from pigs in Spain

Abstract

Keywords

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