TY - JOUR
T1 - Mutagenic evaluation of the organophosphorus insecticides methyl parathion and triazophos in drosophila melanogaster
AU - Velazquez, Antonia
AU - Xamena, Noel
AU - Creus, Amadeu
AU - Marcos, Ricardo
PY - 1990/1/1
Y1 - 1990/1/1
N2 - The possible genotoxic effects of the organophosphorus insecticides methyl parathion and triazophos were evaluated by their ability to induce gene and chromosome mutations in male germ cells of Drosophila melanogaster. Sex-linked recessive lethal (SLRL), total and partial sex-chromosome losses (SCL), and non-disjunction (ND) assays were conducted. The routes of administration included adult feeding, injection, and larval feeding. Methyl parathion was unable to induce point mutations or chromosome mutations, although a small increase in the frequency of non-disjunction was detected after larval treatment. Triazophos induced point mutations when assayed in the SLRL test and induced a weak increase in the non-disjunction frequency, but gave negative results in the SCL test. © 1988 by Hemisphere Publishing Corporation.
AB - The possible genotoxic effects of the organophosphorus insecticides methyl parathion and triazophos were evaluated by their ability to induce gene and chromosome mutations in male germ cells of Drosophila melanogaster. Sex-linked recessive lethal (SLRL), total and partial sex-chromosome losses (SCL), and non-disjunction (ND) assays were conducted. The routes of administration included adult feeding, injection, and larval feeding. Methyl parathion was unable to induce point mutations or chromosome mutations, although a small increase in the frequency of non-disjunction was detected after larval treatment. Triazophos induced point mutations when assayed in the SLRL test and induced a weak increase in the non-disjunction frequency, but gave negative results in the SCL test. © 1988 by Hemisphere Publishing Corporation.
U2 - 10.1080/15287399009531458
DO - 10.1080/15287399009531458
M3 - Article
VL - 31
SP - 313
EP - 325
JO - Journal of Toxicology and Environmental Health
JF - Journal of Toxicology and Environmental Health
SN - 0098-4108
IS - 4
ER -