TY - JOUR
T1 - Muscular and glenohumeral changes in the shoulder after brachial plexus birth palsy: An MRI study in a rat model
AU - Soldado, Francisco
AU - Benito-Castillo, David
AU - Fontecha, Cesar G.
AU - Barber, Ignasi
AU - Marotta, Mario
AU - Haddad, Sleiman
AU - Menendez, Mariano E.
AU - Mascarenhas, Vasco V.
AU - Kozin, Scott H.
PY - 2012/12/6
Y1 - 2012/12/6
N2 - Background: Shoulder abnormalities are the major cause of morbidity in upper brachial plexus birth palsy (BPBP). We developed a rat model of upper trunk BPBP and compared our findings to previously reported animal models and to clinical findings in humans.Methods: Forty-three 5-day-old newborn rats underwent selective upper trunk neurectomy of the right brachial plexus and were studied 3 to 20 weeks after surgery. The passive shoulder external rotation was measured and the shoulder joint was assessed bilaterally by a 7.2T MRI bilaterally.Results: We found a marked decrease in passive shoulder external rotation, associated with a severe subscapularis muscle atrophy and contracture. None however developed the typical pattern of glenohumeral dysplasia.Conclusions: In contradiction with previous reports, our study shows that the rat model is not adequate for preclinical studies of shoulder dysplasia. However, it might serve as a useful model for studies analyzing shoulder contracture occurring after upper BPBP. © 2012 Soldado et al.; licensee BioMed Central Ltd.
AB - Background: Shoulder abnormalities are the major cause of morbidity in upper brachial plexus birth palsy (BPBP). We developed a rat model of upper trunk BPBP and compared our findings to previously reported animal models and to clinical findings in humans.Methods: Forty-three 5-day-old newborn rats underwent selective upper trunk neurectomy of the right brachial plexus and were studied 3 to 20 weeks after surgery. The passive shoulder external rotation was measured and the shoulder joint was assessed bilaterally by a 7.2T MRI bilaterally.Results: We found a marked decrease in passive shoulder external rotation, associated with a severe subscapularis muscle atrophy and contracture. None however developed the typical pattern of glenohumeral dysplasia.Conclusions: In contradiction with previous reports, our study shows that the rat model is not adequate for preclinical studies of shoulder dysplasia. However, it might serve as a useful model for studies analyzing shoulder contracture occurring after upper BPBP. © 2012 Soldado et al.; licensee BioMed Central Ltd.
KW - Erb's palsy
KW - Glenohumeral dysplasia
KW - Shoulder anomalies following brachial plexus birth palsy
KW - Shoulder internal rotation contracture
U2 - https://doi.org/10.1186/1749-7221-7-9
DO - https://doi.org/10.1186/1749-7221-7-9
M3 - Article
VL - 7
JO - Journal of Brachial Plexus and Peripheral Nerve Injury
JF - Journal of Brachial Plexus and Peripheral Nerve Injury
SN - 1749-7221
M1 - 9
ER -