Multivisceral resection for locally advanced rectal cancer: Prognostic factors influencing outcome

María Joé Mañas*, E. Espín, M. López-Cano, F. Vallribera, M. Armengol-Carrasco

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Abstract

Aims: To assess outcome in patients with locally advanced rectal cancer undergoing multivisceral resection. Methods: Retrospective study of 30 consecutive patients (mean age 67.8 years) with primary locally advanced rectal cancer undergoing en bloc multivisceral resection of the organs involved with curative intent between 1998 and 2010. Overall survival, local and distal recurrence, and disease-free survival were analyzed by the Kaplan–Meier method. Risk factors for clinical outcome were obtained using a Cox multivariate model. Results: Postoperative complications occurred in 76.7% of patients and the in-hospital mortality rate was 10%. The median follow-up was 28.8 months. A total of 19 patients died at follow-up. Of the 11 patients who were alive, 7 were free of disease. In the multivariate analysis, lymph node involvement, stage II, and lymph vascular invasion were significantly associated with survival, and stage III showed a strong trend towards significance. Suture dehiscence (peritonitis and intra-abdominal abscess) showed a significant trend towards a higher local recurrence. Lymph vascular invasion was associated with a higher distant recurrence. Conclusion: Lymph node involvement was associated with worse survival, whereas stage II and absence of lymph vascular invasion were associated with a better survival. Lymph vascular invasion was associated with a higher distant recurrence.

Original languageAmerican English
Pages (from-to)154-160
Number of pages7
JournalScandinavian Journal of Surgery
Volume104
Issue number3
DOIs
Publication statusPublished - 2014

Keywords

  • Locally advanced
  • Locoregional recurrence
  • Multivisceral resection
  • Prognostic factors
  • Rectal cancer
  • Survival

Fingerprint Dive into the research topics of 'Multivisceral resection for locally advanced rectal cancer: Prognostic factors influencing outcome'. Together they form a unique fingerprint.

Cite this