Multisystemic lymphoplasmacytic inflammation associated with PCV‐3 in wasting pigs

Jaume Alomar, Viviane Saporiti, Mònica Pérez, Diogo Gonçalvez, Marina Sibila, Joaquim Segalés

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10 Citations (Web of Science)


Porcine circovirus 3 (PCV-3) has been detected in diseased and healthy pigs of different ages. Several reports have associated the agent with reproductive failure and mummified and stillborn piglets. One report from North America has proposed a consistent potential association with postweaning disorders. Thus, the present case report aimed to describe the histopathological lesions and their association with the presence of PCV-3 genome in postweaning pigs showing growth-retardation and thrown-back ears. All affected animals displayed multi-organic lymphoplasmacytic periarteritis, lymphocytic myocarditis and/or lymphoplasmacytic meningoencephalitis. PCV-3 genetic material was detected by in situ hybridization within the lesions and confirmed by PCV-3 real-time quantitative PCR detection in tissues. This study represents the first report of PCV-3 associated with clinical disease in postweaning pigs in Europe.

Original languageEnglish
Number of pages6
JournalTransboundary and emerging diseases
Issue number6
Publication statusPublished - 6 Nov 2021


  • in situ hybridization
  • myocarditis
  • periarteritis
  • pig
  • porcine circovirus 3
  • postweaning


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