Multiple determinations of sperm DNA fragmentation show that varicocelectomy is not indicated for infertile patients with subclinical varicocele

Agustin Garcia Peiro, Jordi Ribas Maynou, Maria Oliver Bonet, Joaquima Navarro Ferrete, Alexandros Nikolau, Maria Jose Amengual Guedan, Carlos Abad, Jordi Benet Catala

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Abstract

Varicocele is one of the most common causes of low semen quality, which is reflected in high percentages of sperm cells with fragmented DNA. While varicocelectomy is usually performed to ameliorate a patient's fertility, its impact on sperm DNA integrity in the case of subclinical varicocele is poorly documented. In this study, multiple DNA fragmentation analyses (TUNEL, SCD, and SCSA) were performed on semen samples from sixty infertile patients with varicocele (15 clinical varicoceles, 19 clinical varicoceles after surgical treatment, 16 subclinical varicoceles, and 10 subclinical varicoceles after surgical treatment). TUNEL, SCD, and SCSA assays all showed substantial sperm DNA fragmentation levels that were comparable between subclinical and clinical varicocele patients. Importantly, varicocelectomy did improve sperm quality in patients with clinical varicocele; however, this was not the case in patients with subclinical varicocele. In summary, although infertile patients with clinical and subclinical varicocele have similar sperm DNA quality, varicocelectomy should only be advised for patients with clinical varicocele. © 2014 Agustín García-Peiró et al.
Original languageEnglish
Article number181396
Pages (from-to)181396-
JournalBiomed Res
Volume2014
DOIs
Publication statusPublished - 1 Jan 2014

Fingerprint Dive into the research topics of 'Multiple determinations of sperm DNA fragmentation show that varicocelectomy is not indicated for infertile patients with subclinical varicocele'. Together they form a unique fingerprint.

Cite this