Multiple adverse drug reactions and genetic polymorphism testing

Ana Lucía Arellano, Marta Martin-Subero, Mar Monerris, Adrián Llerena, Magí Farré, Eva Montané

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Abstract

Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. Rationale: Defects in drug metabolic pathways could explain why some patients have a history of multiple adverse drug reactions (ADR); therefore we aimed to analyze genetic polymorphisms in a patient with multiple ADR related to drugs with a common hepatic metabolic pathway through CYP2D6. Patient concerns: We report a patient with psychosis and hypertension related to amitriptyline, tramadol, and duloxetine within a 2-year period. Interventions and Outcomes: A pharmacogenetic test was performed to assess the causative role of the CYP2D6 enzyme, but did not demonstrate a metabolic deficiency. Lessons: Although negative results in the reported case; typing for cytochrome P450 isoenzyme polymorphisms could be a useful diagnostic tool in some patients with a history of multiple ADR.
Original languageEnglish
Article numbere8505
JournalMedicine (United States)
Volume96
Issue number45
DOIs
Publication statusPublished - 1 Nov 2017

Keywords

  • CYP2D6
  • adverse drug reactions
  • drug metabolism
  • genetic polymorphism
  • multiple drug intolerance syndrome

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