Multiparametric assay to screen and dissect the mode of action of anti-human immunodeficiency virus envelope drugs

Julià Blanco, Imma Clotet-Codina, Berta Bosch, Mercedes Armand-Ugón, Bonaventura Clotet, José A. Esté

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Abstract

A flow cytometry-based assay was used to simultaneously quantify X4 and R5 human immunodeficiency virus (HIV) envelope-mediated cell-to-cell viral transfer, cell death, and cell-to-cell fusion. In this assay, different anti-HIV envelope drugs showed characteristic inhibitory profiles for each measured parameter, allowing for the rapid identification of the mode of action of active compounds. Copyright © 2005, American Society for Microbiology. All Rights Reserved.
Original languageEnglish
Pages (from-to)3926-3929
JournalAntimicrobial Agents and Chemotherapy
Volume49
Issue number9
DOIs
Publication statusPublished - 1 Sep 2005

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