Multidisciplinary approach as a model for detection and monitoring of psichiatric morbidity in patients treated with interferon and ribavirin

Marta Cabré Serres, N. Rudi Sola, C. Pontes García, M. Vergara Gómez, I. Parra Uribe, M. Q. Gorgas Torner

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3 Citations (Scopus)


Purpose: We aimed to describe the incidence of psychiatric disorders in a cohort of HCV infected patients treated with interferon and ribavirin, and their impact on treatment adherence and viral response rate (SVR). Materials and methods: Retrospective analysis of a cohort of HCV patients visited at an outpatient pharmacy service (OPS). We included all adult patients monoinfected with HCV who had initiated treatment in 2010. Monitoring of psychiatric disorders was assessed at weeks 0, 4, 12, 24, 48, and 72 through the self-administered questionnaires Hospital Anxiety and Depression Scale (HADS) and General Health Questionnaire (Goldberg). Adherence to treatment was assessed by counting of drug dispensations and patient reporting and drug exposure with the 80/80/80 rule. Virologic response was determined by the physician according to standard definitions. Results: Among 76 included patients, 19 (25%) had a preexisting psychiatric disorder. The incidence of confirmed psychiatric disorders was 33% (n=25), with a peak of abnormal results in the tests by week 12. Overall, 43% of patients achieved an SVR. There were not significant differences between strict adherence and SVR in patients with or without medically confirmed disorders (96.0% vs 96,8%; p = NS) and SVR (39% vs 52%; p = NS], respectively. Conclusions: Psychiatric side effects had no effect on adherence to treatment nor on attainment of SVR. Multidisciplinary monitoring provided during the treatment of hepatitis C can contribute to early detection and management of psychiatric disorders and to improve integrated patient care.
Original languageEnglish
Pages (from-to)162-168
JournalFarmacia Hospitalaria
Issue number3
Publication statusPublished - 1 Jan 2014


  • Anxiety disorders
  • Depressive dissorder
  • Hepatitis C
  • Interdisciplinary communication
  • Interferon-alpha
  • Ribavirin


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